Autoregulation of TCR V region epitopes in autoimmune disease

S. F. Schluter, E. Wang, J. B. Winfield, D. E. Yocum, J. J. Marchalonis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Normal individuals possess low levels of autoantibodies specific for certain peptide defined regions of T-cell receptor (Tcr) variable regions, particularly CDR1 and Fr3. These regions are predicted to be exposed on the surface of the native molecule and, by analogy and comparison with immunoglobulins, correspond to public idiotype determinants. The anti-Tcr idiotype antibodies appear to be ubiquitous and we propose that they play a role in the regulation of T-cell function. To delineate the parameters of expression of these antibodies, we characterized anti-Tcr antibody activity in normal individuals, in those suffering from the autoimmune diseases rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and in patients with non-autoimmune arthritis (osteoarthritis) as a disease control. There were significant increases in autoantibody levels in the autoimmune patients. There was also variation in isotype and the particular variable regions recognized. IgM autoantibodies directed against a few peptide defined determinants were elevated in RA, whereas SLE patient sera showed high levels of IgG binding to a broad spectrum of Tcr peptides.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalAdvances in Experimental Medicine and Biology
Volume383
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

T-Cell Antigen Receptor
Autoimmune Diseases
Epitopes
Homeostasis
Autoantibodies
Systemic Lupus Erythematosus
Peptides
Antibodies
Rheumatoid Arthritis
Disease control
T-cells
Osteoarthritis
Arthritis
Immunoglobulin M
Immunoglobulins
Immunoglobulin G
T-Lymphocytes
Molecules
Serum
Thomsen-Friedenreich antibodies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Schluter, S. F., Wang, E., Winfield, J. B., Yocum, D. E., & Marchalonis, J. J. (1995). Autoregulation of TCR V region epitopes in autoimmune disease. Advances in Experimental Medicine and Biology, 383, 231-236.

Autoregulation of TCR V region epitopes in autoimmune disease. / Schluter, S. F.; Wang, E.; Winfield, J. B.; Yocum, D. E.; Marchalonis, J. J.

In: Advances in Experimental Medicine and Biology, Vol. 383, 1995, p. 231-236.

Research output: Contribution to journalArticle

Schluter, SF, Wang, E, Winfield, JB, Yocum, DE & Marchalonis, JJ 1995, 'Autoregulation of TCR V region epitopes in autoimmune disease', Advances in Experimental Medicine and Biology, vol. 383, pp. 231-236.
Schluter, S. F. ; Wang, E. ; Winfield, J. B. ; Yocum, D. E. ; Marchalonis, J. J. / Autoregulation of TCR V region epitopes in autoimmune disease. In: Advances in Experimental Medicine and Biology. 1995 ; Vol. 383. pp. 231-236.
@article{2a6f344d01484d59b39c4d2381991b1b,
title = "Autoregulation of TCR V region epitopes in autoimmune disease",
abstract = "Normal individuals possess low levels of autoantibodies specific for certain peptide defined regions of T-cell receptor (Tcr) variable regions, particularly CDR1 and Fr3. These regions are predicted to be exposed on the surface of the native molecule and, by analogy and comparison with immunoglobulins, correspond to public idiotype determinants. The anti-Tcr idiotype antibodies appear to be ubiquitous and we propose that they play a role in the regulation of T-cell function. To delineate the parameters of expression of these antibodies, we characterized anti-Tcr antibody activity in normal individuals, in those suffering from the autoimmune diseases rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and in patients with non-autoimmune arthritis (osteoarthritis) as a disease control. There were significant increases in autoantibody levels in the autoimmune patients. There was also variation in isotype and the particular variable regions recognized. IgM autoantibodies directed against a few peptide defined determinants were elevated in RA, whereas SLE patient sera showed high levels of IgG binding to a broad spectrum of Tcr peptides.",
author = "Schluter, {S. F.} and E. Wang and Winfield, {J. B.} and Yocum, {D. E.} and Marchalonis, {J. J.}",
year = "1995",
language = "English",
volume = "383",
pages = "231--236",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer New York",

}

TY - JOUR

T1 - Autoregulation of TCR V region epitopes in autoimmune disease

AU - Schluter, S. F.

AU - Wang, E.

AU - Winfield, J. B.

AU - Yocum, D. E.

AU - Marchalonis, J. J.

PY - 1995

Y1 - 1995

N2 - Normal individuals possess low levels of autoantibodies specific for certain peptide defined regions of T-cell receptor (Tcr) variable regions, particularly CDR1 and Fr3. These regions are predicted to be exposed on the surface of the native molecule and, by analogy and comparison with immunoglobulins, correspond to public idiotype determinants. The anti-Tcr idiotype antibodies appear to be ubiquitous and we propose that they play a role in the regulation of T-cell function. To delineate the parameters of expression of these antibodies, we characterized anti-Tcr antibody activity in normal individuals, in those suffering from the autoimmune diseases rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and in patients with non-autoimmune arthritis (osteoarthritis) as a disease control. There were significant increases in autoantibody levels in the autoimmune patients. There was also variation in isotype and the particular variable regions recognized. IgM autoantibodies directed against a few peptide defined determinants were elevated in RA, whereas SLE patient sera showed high levels of IgG binding to a broad spectrum of Tcr peptides.

AB - Normal individuals possess low levels of autoantibodies specific for certain peptide defined regions of T-cell receptor (Tcr) variable regions, particularly CDR1 and Fr3. These regions are predicted to be exposed on the surface of the native molecule and, by analogy and comparison with immunoglobulins, correspond to public idiotype determinants. The anti-Tcr idiotype antibodies appear to be ubiquitous and we propose that they play a role in the regulation of T-cell function. To delineate the parameters of expression of these antibodies, we characterized anti-Tcr antibody activity in normal individuals, in those suffering from the autoimmune diseases rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and in patients with non-autoimmune arthritis (osteoarthritis) as a disease control. There were significant increases in autoantibody levels in the autoimmune patients. There was also variation in isotype and the particular variable regions recognized. IgM autoantibodies directed against a few peptide defined determinants were elevated in RA, whereas SLE patient sera showed high levels of IgG binding to a broad spectrum of Tcr peptides.

UR - http://www.scopus.com/inward/record.url?scp=0028812613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028812613&partnerID=8YFLogxK

M3 - Article

VL - 383

SP - 231

EP - 236

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -