Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome

Thozhukat Sathyapalan, John Shepherd, Anne Marie Coady, Eric S. Kilpatrick, Stephen Atkin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: It has been shown that there is an increase in oxidative stress in polycystic ovary syndrome (PCOS). Statins are considered to have a pleiotropic effect other than their lipid-lowering effect. These effects may be mediated in part by reducing oxidative stress. Methods: This randomized, double-blind, placebo-controlled study was conducted to assess the effect of atorvastatin on serum malondialdehyde (MDA) concentrations as a marker of oxidative stress in patients with PCOS. Forty medication-naïve patients with PCOS were randomized to either atorvastatin 20 mg daily or placebo for 3 months. A 3-month extension study for both groups of patients was undertaken with metformin 1500 mg daily after completing initial 3 months of atorvastatin or placebo. Results: There was a significant decrease of MDA concentrations with atorvastatin [mean (SEM)] [0.29 (0.04) vs. 0.25 (0.02) μmol/liter; P < 0.01] compared with placebo [0.28 (0.02) vs. 0.29 (0.12) μmol/liter; P = 0.52]. Three months treatment with metformin resulted in further reduction of MDA levels with atorvastatin compared with baseline [0.25 (0.02) baseline vs. 0.23 (0.03) μmol/liter for atorvastatin treated; P = 0.02]. There was also a significant correlation between the reduction in MDA with a reduction in high-sensitivity C-reactive protein (r = 0.71, P < 0.01), an increase in 25-hydroxyvitamin D (25OHD; r = -0.68, P = 0.02), and a reduction in testosterone levels (r = 0.63, P = 0.01). Multiple linear regression analysis revealed Δ25OHD, ΔC-reactive protein, and Δtestosterone were independent predictors of changes in MDA after atorvastatin treatment. No correlation was observed between the reductions in serum MDA concentrations with changes in the lipid parameters. Conclusions: Twelve weeks of atorvastatin led to a significant reduction in oxidative stress as determined by MDA concentrations among patients with polycystic ovary syndrome that was independently predicted by changes in testosterone, 25OHD, and high-sensitivity C-reactive protein.

Original languageEnglish
Pages (from-to)3951-3955
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number11
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

Fingerprint

Polycystic Ovary Syndrome
Malondialdehyde
Oxidative stress
Oxidative Stress
Placebos
C-Reactive Protein
Testosterone
Metformin
Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Atorvastatin Calcium
Serum
Linear regression
Regression analysis
Linear Models
Regression Analysis
Scanning electron microscopy
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome. / Sathyapalan, Thozhukat; Shepherd, John; Coady, Anne Marie; Kilpatrick, Eric S.; Atkin, Stephen.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 11, 11.2012, p. 3951-3955.

Research output: Contribution to journalArticle

Sathyapalan, Thozhukat ; Shepherd, John ; Coady, Anne Marie ; Kilpatrick, Eric S. ; Atkin, Stephen. / Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 11. pp. 3951-3955.
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abstract = "Background: It has been shown that there is an increase in oxidative stress in polycystic ovary syndrome (PCOS). Statins are considered to have a pleiotropic effect other than their lipid-lowering effect. These effects may be mediated in part by reducing oxidative stress. Methods: This randomized, double-blind, placebo-controlled study was conducted to assess the effect of atorvastatin on serum malondialdehyde (MDA) concentrations as a marker of oxidative stress in patients with PCOS. Forty medication-na{\"i}ve patients with PCOS were randomized to either atorvastatin 20 mg daily or placebo for 3 months. A 3-month extension study for both groups of patients was undertaken with metformin 1500 mg daily after completing initial 3 months of atorvastatin or placebo. Results: There was a significant decrease of MDA concentrations with atorvastatin [mean (SEM)] [0.29 (0.04) vs. 0.25 (0.02) μmol/liter; P < 0.01] compared with placebo [0.28 (0.02) vs. 0.29 (0.12) μmol/liter; P = 0.52]. Three months treatment with metformin resulted in further reduction of MDA levels with atorvastatin compared with baseline [0.25 (0.02) baseline vs. 0.23 (0.03) μmol/liter for atorvastatin treated; P = 0.02]. There was also a significant correlation between the reduction in MDA with a reduction in high-sensitivity C-reactive protein (r = 0.71, P < 0.01), an increase in 25-hydroxyvitamin D (25OHD; r = -0.68, P = 0.02), and a reduction in testosterone levels (r = 0.63, P = 0.01). Multiple linear regression analysis revealed Δ25OHD, ΔC-reactive protein, and Δtestosterone were independent predictors of changes in MDA after atorvastatin treatment. No correlation was observed between the reductions in serum MDA concentrations with changes in the lipid parameters. Conclusions: Twelve weeks of atorvastatin led to a significant reduction in oxidative stress as determined by MDA concentrations among patients with polycystic ovary syndrome that was independently predicted by changes in testosterone, 25OHD, and high-sensitivity C-reactive protein.",
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AU - Atkin, Stephen

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