Association study of proposed candidate genes/regions in a population of Spanish asthmatics

J. B. Soriano, R. De Cid, Xavier P. Estivill, J. M. Antó, J. Sunyer, D. Otero, J. Roca, R. Rodríguez-Roisín, F. Morell, M. J. Rodrigo, G. Ercilla, T. H. Beaty, C. Lázaro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A number of genes/regions have recently been reported to be linked to asthma or its related phenotypes (i.e. atopy and bronchial hyperresponsiveness), by genetic linkage and allele-sharing methods. We have performed a case-control study comparing the allelic distribution of nine microsatellite markers and two genetic variants in a group of patients attended at emergency room departments because of an acute attack of asthma with respect to an external healthy population of controls. A total of 146 asthmatic subjects and 50 population controls from Barcelona, Spain, were genotyped for nine microsatellite markers from some asthma/atopy candidate genes/regions: the β-subunit of the high-affinity IgE receptor (FcεRI-β) located on chromosome 11; the 5q31-32 candidate region; the T-cell receptor genes, TCR-α on chromosome 14 and TCR-β on chromosome 7. Two genetic variants of the β-subunit of the high-affinity IgE receptor (FcεRI-β) gene were also analyzed. None of the asthmatic or control individuals carried the Ile181Leu variant. There were no significant differences between asthmatic and control subjects neither for the polymorphic markers nor for the other variant of the β-subunit of the high-affinity IgE receptor (FcεRI-β) gene. No association could be observed in this sample of Spanish asthmatics with the genes/regions studied.

Original languageEnglish
Pages (from-to)745-750
Number of pages6
JournalEuropean Journal of Epidemiology
Volume16
Issue number8
DOIs
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Genetic Association Studies
IgE Receptors
Population Control
Asthma
Population
Genes
Microsatellite Repeats
Hospital Emergency Service
T-Cell Receptor Genes
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 11
Genetic Linkage
Chromosomes, Human, Pair 7
Spain
Case-Control Studies
Alleles
Phenotype

Keywords

  • Association
  • Asthma
  • Atopy
  • Bronchial hyperresponsiveness
  • Candidate genes
  • Linkage disequilibrium

ASJC Scopus subject areas

  • Epidemiology

Cite this

Association study of proposed candidate genes/regions in a population of Spanish asthmatics. / Soriano, J. B.; De Cid, R.; Estivill, Xavier P.; Antó, J. M.; Sunyer, J.; Otero, D.; Roca, J.; Rodríguez-Roisín, R.; Morell, F.; Rodrigo, M. J.; Ercilla, G.; Beaty, T. H.; Lázaro, C.

In: European Journal of Epidemiology, Vol. 16, No. 8, 2000, p. 745-750.

Research output: Contribution to journalArticle

Soriano, JB, De Cid, R, Estivill, XP, Antó, JM, Sunyer, J, Otero, D, Roca, J, Rodríguez-Roisín, R, Morell, F, Rodrigo, MJ, Ercilla, G, Beaty, TH & Lázaro, C 2000, 'Association study of proposed candidate genes/regions in a population of Spanish asthmatics', European Journal of Epidemiology, vol. 16, no. 8, pp. 745-750. https://doi.org/10.1023/A:1026758319621
Soriano, J. B. ; De Cid, R. ; Estivill, Xavier P. ; Antó, J. M. ; Sunyer, J. ; Otero, D. ; Roca, J. ; Rodríguez-Roisín, R. ; Morell, F. ; Rodrigo, M. J. ; Ercilla, G. ; Beaty, T. H. ; Lázaro, C. / Association study of proposed candidate genes/regions in a population of Spanish asthmatics. In: European Journal of Epidemiology. 2000 ; Vol. 16, No. 8. pp. 745-750.
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AU - Sunyer, J.

AU - Otero, D.

AU - Roca, J.

AU - Rodríguez-Roisín, R.

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