Association study of a MAO-A gene promoter polymorphism in panic disorder patients

M. Gratacòs, R. Martín-Santos, G. Pérez, A. Bulbena, J. Deckert, Xavier P. Estivill

Research output: Contribution to journalArticle

Abstract

A recent association study of a functional VNTR polymorphism in the MAOA-gene promoter in two independent samples with panic disorder (Deckert et al.,1999) showed that longer alleles occurred more frequently among females with panic disorder. We investigated 48 patients of Spanish origin with panic disorder with or without agoraphobia. The female group with paric disorder had longer alleles (3a, 4 or 5) more frequently than the control group (2=8.84; p=0.003). Indeed, those genotypes only composed by long alleles were also more frequent among female patients with panic disorder (2=6.7; p=0.007). No statistically significant differences were observed in the distribution of alleles nor genotypes in the male group. There were no differences when distributions betweer males and females were compared in the control and panic group. For the female group, the relative risk of suffering; panic disorder when having a homozygous genotype for king alleles respect to heterozygosity is 2.13 (CI 95%=0.99-4.59) and in the case of being homozygous for short alleles is 2.03 (CI 95%=1.02-4.05). Our study confirms the observed association of longer alleles in females with panic disorder.

Original languageEnglish
Pages (from-to)556-557
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume96
Issue number4
Publication statusPublished - 7 Aug 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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