Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons

Michaela Pichler, Barbara Kollerits, Iris M. Heid, Steven Hunt, Ted D. Adams, Paul N. Hopkins, Florian Kronenberg

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Several studies have reported that carriers of the 103I allele of the melanocortin-4 receptor (MC4R) gene had lower body weight than did persons with the wild-type genotype. A recent study found an association of the MC4R 103I variant with carbohydrate intake, which may mediate some of the association of this variant with leanness. Objective: The purpose of the study was to investigate the association between the MC4R V 103I polymorphism and the dietary intake of persons with severe obesity, which was derived by using the Willett food-frequency questionnaire. Design: The MC4R V103I polymorphism was genotyped in a group of 1029 severely obese white subjects with an average body mass index (BMI; in kg/m2) of 46.0 (range: 33-92). Results: Carriers of the 103I allele had significantly higher daily energy (364 kcal/d or 19%; P = 0.03) and carbohydrate (57 g/d or 27%; P = 0.01) intakes than did noncarriers, but there was no relation with BMI. No notable association of this polymorphism with lipid and glucose variables of the metabolic syndrome was observed. Conclusions: The higher dietary intake of carbohydrates in severely obese persons with the MC4R 103I variant is in line with previous findings. It may indicate a differential effect on body size measures in extremely obese subjects as compared with the general population.

Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Volume88
Issue number3
Publication statusPublished - 1 Sep 2008
Externally publishedYes

Fingerprint

Receptor, Melanocortin, Type 4
food intake
genetic polymorphism
receptors
Alleles
Carbohydrates
Body Weights and Measures
Dietary Carbohydrates
carbohydrates
alleles
carbohydrate intake
Morbid Obesity
Thinness
metabolic syndrome
food frequency questionnaires
Body Size
body mass index
Body Mass Index
obesity
body size

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Pichler, M., Kollerits, B., Heid, I. M., Hunt, S., Adams, T. D., Hopkins, P. N., & Kronenberg, F. (2008). Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons. American Journal of Clinical Nutrition, 88(3), 797-800.

Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons. / Pichler, Michaela; Kollerits, Barbara; Heid, Iris M.; Hunt, Steven; Adams, Ted D.; Hopkins, Paul N.; Kronenberg, Florian.

In: American Journal of Clinical Nutrition, Vol. 88, No. 3, 01.09.2008, p. 797-800.

Research output: Contribution to journalArticle

Pichler, M, Kollerits, B, Heid, IM, Hunt, S, Adams, TD, Hopkins, PN & Kronenberg, F 2008, 'Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons', American Journal of Clinical Nutrition, vol. 88, no. 3, pp. 797-800.
Pichler, Michaela ; Kollerits, Barbara ; Heid, Iris M. ; Hunt, Steven ; Adams, Ted D. ; Hopkins, Paul N. ; Kronenberg, Florian. / Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons. In: American Journal of Clinical Nutrition. 2008 ; Vol. 88, No. 3. pp. 797-800.
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