Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons

Michaela Pichler, Barbara Kollerits, Iris M. Heid, Steven C. Hunt, Ted D. Adams, Paul N. Hopkins, Florian Kronenberg

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Background: Several studies have reported that carriers of the 103I allele of the melanocortin-4 receptor (MC4R) gene had lower body weight than did persons with the wild-type genotype. A recent study found an association of the MC4R 103I variant with carbohydrate intake, which may mediate some of the association of this variant with leanness. Objective: The purpose of the study was to investigate the association between the MC4R V 103I polymorphism and the dietary intake of persons with severe obesity, which was derived by using the Willett food-frequency questionnaire. Design: The MC4R V103I polymorphism was genotyped in a group of 1029 severely obese white subjects with an average body mass index (BMI; in kg/m2) of 46.0 (range: 33-92). Results: Carriers of the 103I allele had significantly higher daily energy (364 kcal/d or 19%; P = 0.03) and carbohydrate (57 g/d or 27%; P = 0.01) intakes than did noncarriers, but there was no relation with BMI. No notable association of this polymorphism with lipid and glucose variables of the metabolic syndrome was observed. Conclusions: The higher dietary intake of carbohydrates in severely obese persons with the MC4R 103I variant is in line with previous findings. It may indicate a differential effect on body size measures in extremely obese subjects as compared with the general population.

Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number3
Publication statusPublished - 1 Sep 2008


ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Pichler, M., Kollerits, B., Heid, I. M., Hunt, S. C., Adams, T. D., Hopkins, P. N., & Kronenberg, F. (2008). Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons. American Journal of Clinical Nutrition, 88(3), 797-800.