Association of the FTO gene with BMI

Steven Hunt, Steven Stone, Yuanpei Xin, Christina A. Scherer, Charles L. Magness, Shawn P. Iadonato, Paul N. Hopkins, Ted D. Adams

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects. To replicate these findings, the previously reported SNP in the FTO gene (rs9939609, T/A) was genotyped in 5,607 subjects from five different Utah studies. The studies included a random sample of the Utah population, families selected for aggregation of extreme thinness, families selected for severe obesity, a series of unrelated severe obesity subjects, and families participating in a 25-year longitudinal study of cardiovascular disease and aging. Results show a strong significant increase in the rs9939609 A allele frequency with increasing BMI (P < 0.0001). In the longitudinal study, FTO genotypes were significantly associated with BMI at a baseline exam, a 2 1/2-year follow-up exam and a 25-year follow-up exam using an additive genetic model. The mean genotype difference in BMI ranged from 1.3 to 2.1 kg/m2 across exams. The genotype difference in BMI means was established in youth, and at-risk subjects under age 20 at baseline had a significantly larger 25-year BMI increase (10.0 for A/A; 9.7 for A/T, and 8.5 kg/m2 for T/T, P = 0.05). We conclude that the BMI increases associated with FTO genotypes begin in youth and are maintained throughout adulthood.

Original languageEnglish
Pages (from-to)902-904
Number of pages3
JournalObesity
Volume16
Issue number4
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

Fingerprint

Genotype
Morbid Obesity
Genes
Longitudinal Studies
Thinness
Genetic Models
Gene Frequency
Single Nucleotide Polymorphism
Cardiovascular Diseases
Obesity
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Hunt, S., Stone, S., Xin, Y., Scherer, C. A., Magness, C. L., Iadonato, S. P., ... Adams, T. D. (2008). Association of the FTO gene with BMI. Obesity, 16(4), 902-904. https://doi.org/10.1038/oby.2007.126

Association of the FTO gene with BMI. / Hunt, Steven; Stone, Steven; Xin, Yuanpei; Scherer, Christina A.; Magness, Charles L.; Iadonato, Shawn P.; Hopkins, Paul N.; Adams, Ted D.

In: Obesity, Vol. 16, No. 4, 04.2008, p. 902-904.

Research output: Contribution to journalArticle

Hunt, S, Stone, S, Xin, Y, Scherer, CA, Magness, CL, Iadonato, SP, Hopkins, PN & Adams, TD 2008, 'Association of the FTO gene with BMI', Obesity, vol. 16, no. 4, pp. 902-904. https://doi.org/10.1038/oby.2007.126
Hunt S, Stone S, Xin Y, Scherer CA, Magness CL, Iadonato SP et al. Association of the FTO gene with BMI. Obesity. 2008 Apr;16(4):902-904. https://doi.org/10.1038/oby.2007.126
Hunt, Steven ; Stone, Steven ; Xin, Yuanpei ; Scherer, Christina A. ; Magness, Charles L. ; Iadonato, Shawn P. ; Hopkins, Paul N. ; Adams, Ted D. / Association of the FTO gene with BMI. In: Obesity. 2008 ; Vol. 16, No. 4. pp. 902-904.
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