Association of the FTO gene with BMI

Steven C. Hunt, Steven Stone, Yuanpei Xin, Christina A. Scherer, Charles L. Magness, Shawn P. Iadonato, Paul N. Hopkins, Ted D. Adams

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Abstract

Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects. To replicate these findings, the previously reported SNP in the FTO gene (rs9939609, T/A) was genotyped in 5,607 subjects from five different Utah studies. The studies included a random sample of the Utah population, families selected for aggregation of extreme thinness, families selected for severe obesity, a series of unrelated severe obesity subjects, and families participating in a 25-year longitudinal study of cardiovascular disease and aging. Results show a strong significant increase in the rs9939609 A allele frequency with increasing BMI (P < 0.0001). In the longitudinal study, FTO genotypes were significantly associated with BMI at a baseline exam, a 2 1/2-year follow-up exam and a 25-year follow-up exam using an additive genetic model. The mean genotype difference in BMI ranged from 1.3 to 2.1 kg/m2 across exams. The genotype difference in BMI means was established in youth, and at-risk subjects under age 20 at baseline had a significantly larger 25-year BMI increase (10.0 for A/A; 9.7 for A/T, and 8.5 kg/m2 for T/T, P = 0.05). We conclude that the BMI increases associated with FTO genotypes begin in youth and are maintained throughout adulthood.

Original languageEnglish
Pages (from-to)902-904
Number of pages3
JournalObesity
Volume16
Issue number4
DOIs
Publication statusPublished - 1 Apr 2008

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Hunt, S. C., Stone, S., Xin, Y., Scherer, C. A., Magness, C. L., Iadonato, S. P., Hopkins, P. N., & Adams, T. D. (2008). Association of the FTO gene with BMI. Obesity, 16(4), 902-904. https://doi.org/10.1038/oby.2007.126