Association of recently identified type 2 diabetes gene variants with Gestational Diabetes in Asian Indian population

Sekar Kanthimathi, Chidambaram Manickam, Dhanasekaran Bodhini, Samuel Liju, Aruyerchelvan Bhavatharini, Ram Uma, Ranjit Mohan Anjana, Viswanathan Mohan, Venkatesan Radha

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Abstract

Earlier studies have provided evidence that the gestational diabetes mellitus (GDM) and Type 2 diabetes mellitus (T2DM) share common genetic background. A recent genome wide association study (GWAS) showed a strong association of six novel gene variants with T2DM among south Asians but not with Europeans. The aim of this study was to investigate whether these variants that confer susceptibility to T2DM in Asian Indian population also correlate with GDM in Asian Indian population. In addition to these novel variants, three T2DM associated SNPs that were previously identified by GWAS in Caucasian populations, which also showed association with T2DM in south Indian population in our previous study were also evaluated for their susceptibility to GDM in our population. The study groups comprised unrelated pregnant women with GDM (n = 518) and pregnant women with normal glucose tolerance (NGT) (n = 1220). A total of nine SNPs in or near nine loci, namely AP3S2 (rs2028299), BAZ1B (rs12056034), CDKN2A/B (rs7020996), GRB14 (rs3923113), HHEX (rs7923837), HMG20A (rs7178572), HNF4A (rs4812829), ST6GAL1 (rs16861329) and VPS26A (rs1802295) were genotyped using the MassARRAY system. Among these nine SNPs that previously showed an association with T2DM in Asian Indians, HMG20A (rs7178572) and HNF4A (rs4812829) gene variants showed a significant association with GDM. The risk alleles of rs7178572 in HMG20A and rs4812829 in HNF4A gene conferred 1.24 and 1.28 times higher risk independently and about 1.44 and 1.97 times increased susceptibility to GDM for one and two risk genotypes, respectively. We report that the HMG20A (rs7178572) and HNF4A (rs4812829) variants that have previously shown a strong association with T2DM in Asian Indians also contributes significant risk to GDM in this population. This is the first report of the association of HMG20A (rs7178572) and HNF4A (rs4812829) variants with GDM.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalMolecular Genetics and Genomics
DOIs
Publication statusAccepted/In press - 11 Feb 2017

Fingerprint

Gestational Diabetes
Type 2 Diabetes Mellitus
Population
Genes
Single Nucleotide Polymorphism
Genome-Wide Association Study
Pregnant Women
Alleles
Genotype
Glucose

Keywords

  • Asian Indian
  • GDM
  • GWAS
  • HMG20A (rs7178572)
  • HNF4A (rs4812829)
  • T2DM

ASJC Scopus subject areas

  • Genetics

Cite this

Association of recently identified type 2 diabetes gene variants with Gestational Diabetes in Asian Indian population. / Kanthimathi, Sekar; Manickam, Chidambaram; Bodhini, Dhanasekaran; Liju, Samuel; Bhavatharini, Aruyerchelvan; Uma, Ram; Anjana, Ranjit Mohan; Mohan, Viswanathan; Radha, Venkatesan.

In: Molecular Genetics and Genomics, 11.02.2017, p. 1-7.

Research output: Contribution to journalArticle

Kanthimathi, Sekar ; Manickam, Chidambaram ; Bodhini, Dhanasekaran ; Liju, Samuel ; Bhavatharini, Aruyerchelvan ; Uma, Ram ; Anjana, Ranjit Mohan ; Mohan, Viswanathan ; Radha, Venkatesan. / Association of recently identified type 2 diabetes gene variants with Gestational Diabetes in Asian Indian population. In: Molecular Genetics and Genomics. 2017 ; pp. 1-7.
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