Association of oestrogen receptor α gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone

Omar Al Bagha, U. Pettersson, A. Stewart, F. E.A. McGuigan, H. M. MacDonald, D. M. Reid, Stuart H. Ralston

Research output: Contribution to journalArticle

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Abstract

Background: The gene encoding oestrogen receptor α (ESR1) appears to regulate bone mineral density (BMD) and other determinants of osteoporotic fracture risk. Objective: To investigate the relation between common polymorphisms and haplotypes of the ESR1 gene and osteoporosis related phenotypes in a population based cohort of 3054 Scottish women. Results: There was a significant association between a common haplotype "px", defined by the Pvull and Xbal restriction fragment length polymorphisms within intron 1 of the ESR1 gene, and femoral neck bone loss in postmenopausal women who had not received hormone replacement therapy (n = 945; p = 0.009). Annual rates of femoral neck bone loss were ∼ 14% higher in subjects who carried one copy of px and 22% higher in those who carried two copies, compared with those who did not carry the px haplotype. The px haplotype was associated with lower femoral neck BMD in the postmenopausal women (p = 0.02), and with reduced calcaneal broadband ultrasound attenuation (BUA) values in the whole study population (p = 0.005). There was no association between a TA repeat polymorphism in the ESR1 promoter and any phenotype studied, though on long range haplotype analysis subjects with a smaller number of TA repeats who also carried the px haplotype had reduced BUA values. Conclusions: The ESR1 px haplotype is associated with reduced hip BMD values and increased rates of femoral neck bone loss in postmenopausal women. An association with BUA may explain the fact that ESR1 intron 1 alleles predict osteoporotic fractures by a mechanism partly independent of differences in BMD.

Original languageEnglish
Pages (from-to)240-246
Number of pages7
JournalJournal of Medical Genetics
Volume42
Issue number3
DOIs
Publication statusPublished - Mar 2005
Externally publishedYes

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Postmenopausal Osteoporosis
Estrogen Receptors
Haplotypes
Bone and Bones
Femur Neck
Bone Density
Genes
Osteoporotic Fractures
Introns
Pelvic Bones
Phenotype
Hormone Replacement Therapy
Restriction Fragment Length Polymorphisms
Population
Osteoporosis
Alleles

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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Association of oestrogen receptor α gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone. / Al Bagha, Omar; Pettersson, U.; Stewart, A.; McGuigan, F. E.A.; MacDonald, H. M.; Reid, D. M.; Ralston, Stuart H.

In: Journal of Medical Genetics, Vol. 42, No. 3, 03.2005, p. 240-246.

Research output: Contribution to journalArticle

Al Bagha, Omar ; Pettersson, U. ; Stewart, A. ; McGuigan, F. E.A. ; MacDonald, H. M. ; Reid, D. M. ; Ralston, Stuart H. / Association of oestrogen receptor α gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone. In: Journal of Medical Genetics. 2005 ; Vol. 42, No. 3. pp. 240-246.
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