Association of IL-8 (-251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma

Hela Ben Nasr, Karim Chahed, Souhir Mestiri, Noureddine Bouaouina, Kaouther Snoussi, Lotfi Chouchane

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies including nasopharyngeal carcinoma (NPC). In the present study, we evaluated the susceptibility and prognostic implications of the (-251) T/A genetic variation in IL-8 in NPC. We used the allele-specific polymerase chain reaction to characterize the variation of the IL-8 promoter region for 160 unrelated Tunisian patients with NPC and 169 healthy control subjects. There was a significant association between the homozygotes IL-8 (-251) AA genotype and nasopharyngeal carcinoma (OR = 2.46; P = 0.004). The presence of the IL-8 (-251) AA genotype was highly associated with elevated NPC risk for male patients. A significant association was demonstrated between the IL-8 (-251) AA genotype and the aggressive forms of NPC as defined by large tumor size, lymph node metastasis, and advanced stages. Moreover, the presence of the IL-8 (-251) AA genotype indicated a significant association with decreased overall survival. Our findings suggest that the IL-8 promoter polymorphism is associated with increased nasopharyngeal carcinoma risk, particularly in males, as well as disease progress, supporting our hypothesis for IL-8 involvement in NPC pathogenesis.

Original languageEnglish
Pages (from-to)761-769
Number of pages9
JournalHuman Immunology
Volume68
Issue number9
DOIs
Publication statusPublished - Sep 2007
Externally publishedYes

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Keywords

  • Genetic susceptibility
  • IL-8
  • Nasopharyngeal carcinoma
  • Polymorphism
  • Prognosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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