Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: The National Heart, Lung, and Blood Institute Family Heart Study

Jeremy M. Robbins, Andrew B. Petrone, J. Jeffrey Carr, James S. Pankow, Steven Hunt, Gerardo Heiss, Donna K. Arnett, R. Curtis Ellison, J. Michael Gaziano, Luc Djoussé

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background The American Heart Association (AHA) established recommendations based on 7 ideal health behaviors and factors with the goal of improving cardiovascular health (CVH) and reducing both morbidity and mortality from cardiovascular disease by 20% by 2020. Few studies have investigated their association with subclinical coronary heart disease. We sought to examine whether the 7 AHA CVH metrics were associated with calcified atherosclerotic plaque in the coronary arteries. Methods In a cross-sectional design, we studied 1,731 predominantly white men and women from the National Heart, Lung, and Blood Institute Family Heart Study without prevalent coronary heart disease. Diet was assessed by a semiquantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC using an Agatston score of 100+ and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results Mean age was 56.8 years, and 41% were male. The median number of ideal CVH metrics was 3, and no participant met all 7. There was a strong inverse relationship between number of ideal CVH metrics and prevalent CAC. Odds ratios (95% CI) for CAC of 100+ were 1.0 (reference), 0.37 (0.29-0.45), 0.35 (0.26-0.44), and 0.27 (0.20-0.36) among subjects with 0 to 1, 2, 3, and 4+ ideal CVH metrics, respectively (P =.0001), adjusting for sex, age, field center, alcohol, income, education, and energy consumption. Conclusions These data demonstrate a strong and graded inverse relationship between AHA ideal CVH metrics and prevalent CAC in adult men and women.

Original languageEnglish
Pages (from-to)371-378.e1
JournalAmerican Heart Journal
Volume169
Issue number3
DOIs
Publication statusPublished - 1 Mar 2015
Externally publishedYes

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National Heart, Lung, and Blood Institute (U.S.)
Atherosclerotic Plaques
Coronary Vessels
Calcium
Health
American Heart Association
Coronary Disease
Odds Ratio
Health Behavior
Cardiovascular Diseases
Tomography
Alcohols
Diet
Morbidity
Education
Food
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries : The National Heart, Lung, and Blood Institute Family Heart Study. / Robbins, Jeremy M.; Petrone, Andrew B.; Carr, J. Jeffrey; Pankow, James S.; Hunt, Steven; Heiss, Gerardo; Arnett, Donna K.; Ellison, R. Curtis; Gaziano, J. Michael; Djoussé, Luc.

In: American Heart Journal, Vol. 169, No. 3, 01.03.2015, p. 371-378.e1.

Research output: Contribution to journalArticle

Robbins, Jeremy M. ; Petrone, Andrew B. ; Carr, J. Jeffrey ; Pankow, James S. ; Hunt, Steven ; Heiss, Gerardo ; Arnett, Donna K. ; Ellison, R. Curtis ; Gaziano, J. Michael ; Djoussé, Luc. / Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries : The National Heart, Lung, and Blood Institute Family Heart Study. In: American Heart Journal. 2015 ; Vol. 169, No. 3. pp. 371-378.e1.
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