Association of egg consumption and calcified atherosclerotic plaque in the coronary arteries

The NHLBI Family Heart Study

Jeremy M. Robbins, Andrew B. Petrone, R. Curtis Ellison, Steven Hunt, J. Jeffrey Carr, Gerardo Heiss, Donna K. Arnett, J. Michael Gaziano, Luc Djoussé

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and aims: Eggs are a ubiquitous and important source of dietary cholesterol and nutrients, yet their relationship to coronary heart disease (CHD) remains unclear. While some data have suggested a positive association between egg consumption and CHD, especially among diabetic subjects, limited data exist on the influence of egg consumption on subclinical disease. Thus, we sought to examine whether egg consumption is associated with calcified atherosclerotic plaques in the coronary arteries. Methods: In a cross-sectional design, we studied 1848 participants of the NHLBI Family Heart Study without known CHD. Egg consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac CT. We defined prevalent CAC using an Agatston score of at least 100 and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results: Mean age was 56.5 years and 41% were male. Median consumption of eggs was 1/week. There was no association between frequency of egg consumption and prevalent CAC. Odds ratios (95% CI) for CAC were 1.0 (reference), 0.95 (0.66-1.38), 0.94 (0.63-1.40), and 0.90 (0.57-1.42) for egg consumption of almost never, 1-3 times per month, once per week, and 2+ times per week, respectively (p for trend 0.66), adjusting for age, sex, BMI, smoking, alcohol, physical activity, income, field center, total calories, and bacon. Additional control for hypertension and diabetes mellitus, or restricting the analysis to subjects with diabetes mellitus or fasting glucose >126mg/dL did not alter the findings. Conclusions: These data do not provide evidence for an association between egg consumption and prevalent CAC in adult men and women.

Original languageEnglish
Journale-SPEN Journal
Volume9
Issue number3
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

National Heart, Lung, and Blood Institute (U.S.)
Atherosclerotic Plaques
Ovum
Coronary Vessels
Calcium
Coronary Disease
Eggs
Diabetes Mellitus
Odds Ratio
Dietary Cholesterol
Food
Fasting
Smoking
Alcohols
Exercise
Hypertension
Glucose

Keywords

  • Atherosclerosis
  • CAC
  • CHD
  • CI
  • Coronary calcium
  • CT
  • CVD
  • Diet
  • Egg
  • Epidemiology
  • HDL
  • LDL
  • NHLBI FHS
  • Subclinical disease

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Association of egg consumption and calcified atherosclerotic plaque in the coronary arteries : The NHLBI Family Heart Study. / Robbins, Jeremy M.; Petrone, Andrew B.; Ellison, R. Curtis; Hunt, Steven; Carr, J. Jeffrey; Heiss, Gerardo; Arnett, Donna K.; Gaziano, J. Michael; Djoussé, Luc.

In: e-SPEN Journal, Vol. 9, No. 3, 2014.

Research output: Contribution to journalArticle

Robbins, Jeremy M. ; Petrone, Andrew B. ; Ellison, R. Curtis ; Hunt, Steven ; Carr, J. Jeffrey ; Heiss, Gerardo ; Arnett, Donna K. ; Gaziano, J. Michael ; Djoussé, Luc. / Association of egg consumption and calcified atherosclerotic plaque in the coronary arteries : The NHLBI Family Heart Study. In: e-SPEN Journal. 2014 ; Vol. 9, No. 3.
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abstract = "Background and aims: Eggs are a ubiquitous and important source of dietary cholesterol and nutrients, yet their relationship to coronary heart disease (CHD) remains unclear. While some data have suggested a positive association between egg consumption and CHD, especially among diabetic subjects, limited data exist on the influence of egg consumption on subclinical disease. Thus, we sought to examine whether egg consumption is associated with calcified atherosclerotic plaques in the coronary arteries. Methods: In a cross-sectional design, we studied 1848 participants of the NHLBI Family Heart Study without known CHD. Egg consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac CT. We defined prevalent CAC using an Agatston score of at least 100 and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results: Mean age was 56.5 years and 41{\%} were male. Median consumption of eggs was 1/week. There was no association between frequency of egg consumption and prevalent CAC. Odds ratios (95{\%} CI) for CAC were 1.0 (reference), 0.95 (0.66-1.38), 0.94 (0.63-1.40), and 0.90 (0.57-1.42) for egg consumption of almost never, 1-3 times per month, once per week, and 2+ times per week, respectively (p for trend 0.66), adjusting for age, sex, BMI, smoking, alcohol, physical activity, income, field center, total calories, and bacon. Additional control for hypertension and diabetes mellitus, or restricting the analysis to subjects with diabetes mellitus or fasting glucose >126mg/dL did not alter the findings. Conclusions: These data do not provide evidence for an association between egg consumption and prevalent CAC in adult men and women.",
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T1 - Association of egg consumption and calcified atherosclerotic plaque in the coronary arteries

T2 - The NHLBI Family Heart Study

AU - Robbins, Jeremy M.

AU - Petrone, Andrew B.

AU - Ellison, R. Curtis

AU - Hunt, Steven

AU - Carr, J. Jeffrey

AU - Heiss, Gerardo

AU - Arnett, Donna K.

AU - Gaziano, J. Michael

AU - Djoussé, Luc

PY - 2014

Y1 - 2014

N2 - Background and aims: Eggs are a ubiquitous and important source of dietary cholesterol and nutrients, yet their relationship to coronary heart disease (CHD) remains unclear. While some data have suggested a positive association between egg consumption and CHD, especially among diabetic subjects, limited data exist on the influence of egg consumption on subclinical disease. Thus, we sought to examine whether egg consumption is associated with calcified atherosclerotic plaques in the coronary arteries. Methods: In a cross-sectional design, we studied 1848 participants of the NHLBI Family Heart Study without known CHD. Egg consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac CT. We defined prevalent CAC using an Agatston score of at least 100 and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results: Mean age was 56.5 years and 41% were male. Median consumption of eggs was 1/week. There was no association between frequency of egg consumption and prevalent CAC. Odds ratios (95% CI) for CAC were 1.0 (reference), 0.95 (0.66-1.38), 0.94 (0.63-1.40), and 0.90 (0.57-1.42) for egg consumption of almost never, 1-3 times per month, once per week, and 2+ times per week, respectively (p for trend 0.66), adjusting for age, sex, BMI, smoking, alcohol, physical activity, income, field center, total calories, and bacon. Additional control for hypertension and diabetes mellitus, or restricting the analysis to subjects with diabetes mellitus or fasting glucose >126mg/dL did not alter the findings. Conclusions: These data do not provide evidence for an association between egg consumption and prevalent CAC in adult men and women.

AB - Background and aims: Eggs are a ubiquitous and important source of dietary cholesterol and nutrients, yet their relationship to coronary heart disease (CHD) remains unclear. While some data have suggested a positive association between egg consumption and CHD, especially among diabetic subjects, limited data exist on the influence of egg consumption on subclinical disease. Thus, we sought to examine whether egg consumption is associated with calcified atherosclerotic plaques in the coronary arteries. Methods: In a cross-sectional design, we studied 1848 participants of the NHLBI Family Heart Study without known CHD. Egg consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac CT. We defined prevalent CAC using an Agatston score of at least 100 and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results: Mean age was 56.5 years and 41% were male. Median consumption of eggs was 1/week. There was no association between frequency of egg consumption and prevalent CAC. Odds ratios (95% CI) for CAC were 1.0 (reference), 0.95 (0.66-1.38), 0.94 (0.63-1.40), and 0.90 (0.57-1.42) for egg consumption of almost never, 1-3 times per month, once per week, and 2+ times per week, respectively (p for trend 0.66), adjusting for age, sex, BMI, smoking, alcohol, physical activity, income, field center, total calories, and bacon. Additional control for hypertension and diabetes mellitus, or restricting the analysis to subjects with diabetes mellitus or fasting glucose >126mg/dL did not alter the findings. Conclusions: These data do not provide evidence for an association between egg consumption and prevalent CAC in adult men and women.

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KW - Coronary calcium

KW - CT

KW - CVD

KW - Diet

KW - Egg

KW - Epidemiology

KW - HDL

KW - LDL

KW - NHLBI FHS

KW - Subclinical disease

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