Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome

The National Heart, Lung, and Blood Institute Family Heart Study

Y. H Lana Lai, Andrew B. Petrone, James S. Pankow, Donna K. Arnett, Kari E. North, R. Curtis Ellison, Steven Hunt, Luc Djoussé

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background & aims: Metabolic syndrome (MetS), characterized by abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, and insulin resistance is a major public health concern in the United States. Omega-3 fatty acids have been relatively well studied in relation to many individual cardiovascular risk factors; however, their effects on MetS are not well established. Methods: We conducted a cross-sectional study consisting of 4941 participants from the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study to assess the relation of dietary omega-3 fatty acids with the prevalence of MetS. Omega-3 intake was assessed using a food frequency questionnaire and we used generalized estimating equations to estimate adjusted odds ratios for prevalent MetS. Results: Our study population had a mean age (SD) of 52.1 (13.9) years and 45.9% were men. The mean (SD) of dietary omega-3 fatty acids was 0.25g/day (0.27). From the lowest to the highest quintile of dietary omega-3 fatty acids, multivariable adjusted ORs (95% CI) for MetS were 1.00 (ref), 0.90 (0.72-1.13), 1.03 (0.82-1.28), 0.94 (0.74-1.18), and 0.99 (0.77-1.25), respectively. In a secondary analysis, neither fish consumption nor dietary alpha-linolenic acid was associated with MetS. Conclusions: Our findings do not support an association between dietary omega-3 fatty acids and MetS in a large US population.

Original languageEnglish
Pages (from-to)966-969
Number of pages4
JournalClinical Nutrition
Volume32
Issue number6
DOIs
Publication statusPublished - Dec 2013
Externally publishedYes

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National Heart, Lung, and Blood Institute (U.S.)
Omega-3 Fatty Acids
alpha-Linolenic Acid
Dyslipidemias
Population
Insulin Resistance
Fishes
Public Health
Cross-Sectional Studies
Odds Ratio
Blood Pressure
Food

Keywords

  • Dietary alpha-linolenic acid (ALA)
  • Fish
  • Metabolic syndrome
  • Omega-3 fatty acids

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome : The National Heart, Lung, and Blood Institute Family Heart Study. / Lai, Y. H Lana; Petrone, Andrew B.; Pankow, James S.; Arnett, Donna K.; North, Kari E.; Ellison, R. Curtis; Hunt, Steven; Djoussé, Luc.

In: Clinical Nutrition, Vol. 32, No. 6, 12.2013, p. 966-969.

Research output: Contribution to journalArticle

Lai, Y. H Lana ; Petrone, Andrew B. ; Pankow, James S. ; Arnett, Donna K. ; North, Kari E. ; Ellison, R. Curtis ; Hunt, Steven ; Djoussé, Luc. / Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome : The National Heart, Lung, and Blood Institute Family Heart Study. In: Clinical Nutrition. 2013 ; Vol. 32, No. 6. pp. 966-969.
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AU - Pankow, James S.

AU - Arnett, Donna K.

AU - North, Kari E.

AU - Ellison, R. Curtis

AU - Hunt, Steven

AU - Djoussé, Luc

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