Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade: A pilot study

P. Queirolo, A. Morabito, S. Laurent, S. Lastraioli, P. Piccioli, P. A. Ascierto, G. Gentilcore, M. Serra, A. Marasco, E. Tornari, B. Dozin, M. P. Pistillo

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

CTLA-4 blockade with monoclonal antibodies can lead to cancer regression in patients with metastatic melanoma (MM). CTLA-4 gene polymorphisms may influence the response to anti-CTLA-4 antibodies although few data are available regarding this issue. We analyzed six CTLA-4 single nucleotide polymorphisms (-1661A>G,-1577G>A,-658C>T,-319C>T, +49A>G, and CT60G>A) in 14 Italian MM patients and 45 healthy subjects. We found a significant association between the-1577G/A and CT60G/A genotypes and improved overall survival (Pc < 0.006, Bonferroni corrected), further confirmed by the diplotype analysis (-1577&CT60 GG-AA diplotype, p < 0.001). A positive trend toward an association between these genotypes and response to therapy was also observed.

Original languageEnglish
Pages (from-to)336-345
Number of pages10
JournalCancer Investigation
Volume31
Issue number5
DOIs
Publication statusPublished - 1 Jun 2013
Externally publishedYes

Fingerprint

Melanoma
Genotype
Survival
Single Nucleotide Polymorphism
Healthy Volunteers
Monoclonal Antibodies
Antibodies
Genes
Neoplasms
Therapeutics

Keywords

  • CTLA-4
  • CTLA-4 blockade
  • Melanoma
  • Overall survival
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Queirolo, P., Morabito, A., Laurent, S., Lastraioli, S., Piccioli, P., Ascierto, P. A., ... Pistillo, M. P. (2013). Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade: A pilot study. Cancer Investigation, 31(5), 336-345. https://doi.org/10.3109/07357907.2013.793699

Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade : A pilot study. / Queirolo, P.; Morabito, A.; Laurent, S.; Lastraioli, S.; Piccioli, P.; Ascierto, P. A.; Gentilcore, G.; Serra, M.; Marasco, A.; Tornari, E.; Dozin, B.; Pistillo, M. P.

In: Cancer Investigation, Vol. 31, No. 5, 01.06.2013, p. 336-345.

Research output: Contribution to journalArticle

Queirolo, P, Morabito, A, Laurent, S, Lastraioli, S, Piccioli, P, Ascierto, PA, Gentilcore, G, Serra, M, Marasco, A, Tornari, E, Dozin, B & Pistillo, MP 2013, 'Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade: A pilot study', Cancer Investigation, vol. 31, no. 5, pp. 336-345. https://doi.org/10.3109/07357907.2013.793699
Queirolo, P. ; Morabito, A. ; Laurent, S. ; Lastraioli, S. ; Piccioli, P. ; Ascierto, P. A. ; Gentilcore, G. ; Serra, M. ; Marasco, A. ; Tornari, E. ; Dozin, B. ; Pistillo, M. P. / Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade : A pilot study. In: Cancer Investigation. 2013 ; Vol. 31, No. 5. pp. 336-345.
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