Association of corneal nerve fiber measures with cognitive function in dementia

Georgios Ponirakis, Hanadi Al Hamad, Anoop Sankaranarayanan, Adnan Khan, Mani Chandran, Marwan Ramadan, Rhia Tosino, Priya Vitthal Gawhale, Maryam Alobaidi, Essa AlSulaiti, Ahmed Elsotouhy, Marwa Elorrabi, Shafi Khan, Navas Nadukkandiyil, Susan Osman, Noushad Thodi, Hamad Almuhannadi, Hoda Gad, Ziyad R. Mahfoud, Fatima Al-Shibani & 5 others Ioannis N. Petropoulos, Ahmed Own, Maryam Al Kuwari, Ashfaq Shuaib, Rayaz Malik

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Corneal confocal microscopy (CCM) is a noninvasive ophthalmic technique that identifies corneal nerve degeneration in a range of peripheral neuropathies and in patients with multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis. We sought to determine whether there is any association of corneal nerve fiber measures with cognitive function and functional independence in patients with MCI and dementia. Methods: In this study, 76 nondiabetic participants with MCI (n = 30), dementia (n = 26), and healthy age-matched controls (n = 20) underwent assessment of cognitive and physical function and CCM. Results: There was a progressive reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) (P < 0.0001) in patients with MCI and dementia compared to healthy controls. Adjusted for confounders, all three corneal nerve fiber measures were significantly associated with cognitive function (P < 0.05) and functional independence (P < 0.01) in MCI and dementia. The area under the ROC curve to distinguish MCI with CNFD, CNBD, and CNFL was 69.1%, 73.2%, and 73.0% and for dementia it was 84.8%, 84.2%, and 86.2%, respectively. Interpretation: CCM demonstrates corneal nerve fiber loss, which is associated with a decline in cognitive function and functional independence in patients with MCI and dementia.

Original languageEnglish
Pages (from-to)689-697
Number of pages9
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019

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Nerve Fibers
Cognition
Dementia
Confocal Microscopy
Nerve Degeneration
Amyotrophic Lateral Sclerosis
Peripheral Nervous System Diseases
ROC Curve
Multiple Sclerosis
Area Under Curve
Parkinson Disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Association of corneal nerve fiber measures with cognitive function in dementia. / Ponirakis, Georgios; Al Hamad, Hanadi; Sankaranarayanan, Anoop; Khan, Adnan; Chandran, Mani; Ramadan, Marwan; Tosino, Rhia; Gawhale, Priya Vitthal; Alobaidi, Maryam; AlSulaiti, Essa; Elsotouhy, Ahmed; Elorrabi, Marwa; Khan, Shafi; Nadukkandiyil, Navas; Osman, Susan; Thodi, Noushad; Almuhannadi, Hamad; Gad, Hoda; Mahfoud, Ziyad R.; Al-Shibani, Fatima; Petropoulos, Ioannis N.; Own, Ahmed; Al Kuwari, Maryam; Shuaib, Ashfaq; Malik, Rayaz.

In: Annals of Clinical and Translational Neurology, Vol. 6, No. 4, 01.04.2019, p. 689-697.

Research output: Contribution to journalArticle

Ponirakis, G, Al Hamad, H, Sankaranarayanan, A, Khan, A, Chandran, M, Ramadan, M, Tosino, R, Gawhale, PV, Alobaidi, M, AlSulaiti, E, Elsotouhy, A, Elorrabi, M, Khan, S, Nadukkandiyil, N, Osman, S, Thodi, N, Almuhannadi, H, Gad, H, Mahfoud, ZR, Al-Shibani, F, Petropoulos, IN, Own, A, Al Kuwari, M, Shuaib, A & Malik, R 2019, 'Association of corneal nerve fiber measures with cognitive function in dementia', Annals of Clinical and Translational Neurology, vol. 6, no. 4, pp. 689-697. https://doi.org/10.1002/acn3.746
Ponirakis, Georgios ; Al Hamad, Hanadi ; Sankaranarayanan, Anoop ; Khan, Adnan ; Chandran, Mani ; Ramadan, Marwan ; Tosino, Rhia ; Gawhale, Priya Vitthal ; Alobaidi, Maryam ; AlSulaiti, Essa ; Elsotouhy, Ahmed ; Elorrabi, Marwa ; Khan, Shafi ; Nadukkandiyil, Navas ; Osman, Susan ; Thodi, Noushad ; Almuhannadi, Hamad ; Gad, Hoda ; Mahfoud, Ziyad R. ; Al-Shibani, Fatima ; Petropoulos, Ioannis N. ; Own, Ahmed ; Al Kuwari, Maryam ; Shuaib, Ashfaq ; Malik, Rayaz. / Association of corneal nerve fiber measures with cognitive function in dementia. In: Annals of Clinical and Translational Neurology. 2019 ; Vol. 6, No. 4. pp. 689-697.
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abstract = "Objectives: Corneal confocal microscopy (CCM) is a noninvasive ophthalmic technique that identifies corneal nerve degeneration in a range of peripheral neuropathies and in patients with multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis. We sought to determine whether there is any association of corneal nerve fiber measures with cognitive function and functional independence in patients with MCI and dementia. Methods: In this study, 76 nondiabetic participants with MCI (n = 30), dementia (n = 26), and healthy age-matched controls (n = 20) underwent assessment of cognitive and physical function and CCM. Results: There was a progressive reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) (P < 0.0001) in patients with MCI and dementia compared to healthy controls. Adjusted for confounders, all three corneal nerve fiber measures were significantly associated with cognitive function (P < 0.05) and functional independence (P < 0.01) in MCI and dementia. The area under the ROC curve to distinguish MCI with CNFD, CNBD, and CNFL was 69.1{\%}, 73.2{\%}, and 73.0{\%} and for dementia it was 84.8{\%}, 84.2{\%}, and 86.2{\%}, respectively. Interpretation: CCM demonstrates corneal nerve fiber loss, which is associated with a decline in cognitive function and functional independence in patients with MCI and dementia.",
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T1 - Association of corneal nerve fiber measures with cognitive function in dementia

AU - Ponirakis, Georgios

AU - Al Hamad, Hanadi

AU - Sankaranarayanan, Anoop

AU - Khan, Adnan

AU - Chandran, Mani

AU - Ramadan, Marwan

AU - Tosino, Rhia

AU - Gawhale, Priya Vitthal

AU - Alobaidi, Maryam

AU - AlSulaiti, Essa

AU - Elsotouhy, Ahmed

AU - Elorrabi, Marwa

AU - Khan, Shafi

AU - Nadukkandiyil, Navas

AU - Osman, Susan

AU - Thodi, Noushad

AU - Almuhannadi, Hamad

AU - Gad, Hoda

AU - Mahfoud, Ziyad R.

AU - Al-Shibani, Fatima

AU - Petropoulos, Ioannis N.

AU - Own, Ahmed

AU - Al Kuwari, Maryam

AU - Shuaib, Ashfaq

AU - Malik, Rayaz

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Objectives: Corneal confocal microscopy (CCM) is a noninvasive ophthalmic technique that identifies corneal nerve degeneration in a range of peripheral neuropathies and in patients with multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis. We sought to determine whether there is any association of corneal nerve fiber measures with cognitive function and functional independence in patients with MCI and dementia. Methods: In this study, 76 nondiabetic participants with MCI (n = 30), dementia (n = 26), and healthy age-matched controls (n = 20) underwent assessment of cognitive and physical function and CCM. Results: There was a progressive reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) (P < 0.0001) in patients with MCI and dementia compared to healthy controls. Adjusted for confounders, all three corneal nerve fiber measures were significantly associated with cognitive function (P < 0.05) and functional independence (P < 0.01) in MCI and dementia. The area under the ROC curve to distinguish MCI with CNFD, CNBD, and CNFL was 69.1%, 73.2%, and 73.0% and for dementia it was 84.8%, 84.2%, and 86.2%, respectively. Interpretation: CCM demonstrates corneal nerve fiber loss, which is associated with a decline in cognitive function and functional independence in patients with MCI and dementia.

AB - Objectives: Corneal confocal microscopy (CCM) is a noninvasive ophthalmic technique that identifies corneal nerve degeneration in a range of peripheral neuropathies and in patients with multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis. We sought to determine whether there is any association of corneal nerve fiber measures with cognitive function and functional independence in patients with MCI and dementia. Methods: In this study, 76 nondiabetic participants with MCI (n = 30), dementia (n = 26), and healthy age-matched controls (n = 20) underwent assessment of cognitive and physical function and CCM. Results: There was a progressive reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) (P < 0.0001) in patients with MCI and dementia compared to healthy controls. Adjusted for confounders, all three corneal nerve fiber measures were significantly associated with cognitive function (P < 0.05) and functional independence (P < 0.01) in MCI and dementia. The area under the ROC curve to distinguish MCI with CNFD, CNBD, and CNFL was 69.1%, 73.2%, and 73.0% and for dementia it was 84.8%, 84.2%, and 86.2%, respectively. Interpretation: CCM demonstrates corneal nerve fiber loss, which is associated with a decline in cognitive function and functional independence in patients with MCI and dementia.

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