Association of BDNF with restricting anorexia nervosa and minimum body mass index

A family-based association study of eight European populations

Marta Ribasés, Mònica Gratacòs, Fernando Fernández-Aranda, Laura Bellodi, Claudette Boni, Marija Anderluh, Maria Cristina Cavallini, Elena Cellini, Daniela Di Bella, Stefano Erzegovesi, Christine Foulon, Mojca Gabrovsek, Philip Gorwood, Johannes Hebebrand, Anke Hinney, Jo Holliday, Xun Hu, Andreas Karwautz, Amélie Kipman, Radovan Komel & 9 others Benedetta Nacmias, Helmut Remschmidt, Valdo Ricca, Sandro Sorbi, Martina Tomori, Gudrun Wagner, Janet Treasure, David A. Collier, Xavier P. Estivill

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Eating disorders (ED), such as anorexia nervosa (AN) and bulimia nervosa (BN), are complex psychiatric disorders where different genetic and environmental factors are involved. Several lines of evidence support that brain-derived neurotrophic factor (BDNF) plays an essential role in eating behaviour and that alterations on this neurotrophic system participates in the susceptibility to both AN and BN. Accordingly, intraventricular administration of BDNF in rats determines food starvation and body weight loss, while BDNF or its specific receptor NTRK2 knockout mice develop obesity and hyperphagia. Case-control studies also suggest a BDNF contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the BDNF gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and -270C/T BDNF SNPs and ED in six different European populations. To replicate these results, avoiding population stratification effects, we recruited 453 ED trios from eight European centres and performed a family-based association study. Both haplotype relative risk (HRR) and haplotype-based haplotype relative risk (HHRR) methods showed a positive association between the Met66 allele and ANR. Consistently, we also observed an effect of the Met66 variant on low minBMI and a preferential transmission of the -270C/Met66 haplotype to the affected ANR offspring. These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI.

Original languageEnglish
Pages (from-to)428-434
Number of pages7
JournalEuropean Journal of Human Genetics
Volume13
Issue number4
DOIs
Publication statusPublished - Apr 2005
Externally publishedYes

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Anorexia Nervosa
Brain-Derived Neurotrophic Factor
Body Mass Index
Haplotypes
Population
Bulimia Nervosa
Feeding Behavior
trkB Receptor
Hyperphagia
Inborn Genetic Diseases
Genetic Predisposition to Disease
Starvation
Knockout Mice
Single Nucleotide Polymorphism
Psychiatry
Case-Control Studies
Weight Loss
Obesity
Alleles
Body Weight

Keywords

  • Anorexia
  • BDNF
  • Eating disorders

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Association of BDNF with restricting anorexia nervosa and minimum body mass index : A family-based association study of eight European populations. / Ribasés, Marta; Gratacòs, Mònica; Fernández-Aranda, Fernando; Bellodi, Laura; Boni, Claudette; Anderluh, Marija; Cavallini, Maria Cristina; Cellini, Elena; Di Bella, Daniela; Erzegovesi, Stefano; Foulon, Christine; Gabrovsek, Mojca; Gorwood, Philip; Hebebrand, Johannes; Hinney, Anke; Holliday, Jo; Hu, Xun; Karwautz, Andreas; Kipman, Amélie; Komel, Radovan; Nacmias, Benedetta; Remschmidt, Helmut; Ricca, Valdo; Sorbi, Sandro; Tomori, Martina; Wagner, Gudrun; Treasure, Janet; Collier, David A.; Estivill, Xavier P.

In: European Journal of Human Genetics, Vol. 13, No. 4, 04.2005, p. 428-434.

Research output: Contribution to journalArticle

Ribasés, M, Gratacòs, M, Fernández-Aranda, F, Bellodi, L, Boni, C, Anderluh, M, Cavallini, MC, Cellini, E, Di Bella, D, Erzegovesi, S, Foulon, C, Gabrovsek, M, Gorwood, P, Hebebrand, J, Hinney, A, Holliday, J, Hu, X, Karwautz, A, Kipman, A, Komel, R, Nacmias, B, Remschmidt, H, Ricca, V, Sorbi, S, Tomori, M, Wagner, G, Treasure, J, Collier, DA & Estivill, XP 2005, 'Association of BDNF with restricting anorexia nervosa and minimum body mass index: A family-based association study of eight European populations', European Journal of Human Genetics, vol. 13, no. 4, pp. 428-434. https://doi.org/10.1038/sj.ejhg.5201351
Ribasés, Marta ; Gratacòs, Mònica ; Fernández-Aranda, Fernando ; Bellodi, Laura ; Boni, Claudette ; Anderluh, Marija ; Cavallini, Maria Cristina ; Cellini, Elena ; Di Bella, Daniela ; Erzegovesi, Stefano ; Foulon, Christine ; Gabrovsek, Mojca ; Gorwood, Philip ; Hebebrand, Johannes ; Hinney, Anke ; Holliday, Jo ; Hu, Xun ; Karwautz, Andreas ; Kipman, Amélie ; Komel, Radovan ; Nacmias, Benedetta ; Remschmidt, Helmut ; Ricca, Valdo ; Sorbi, Sandro ; Tomori, Martina ; Wagner, Gudrun ; Treasure, Janet ; Collier, David A. ; Estivill, Xavier P. / Association of BDNF with restricting anorexia nervosa and minimum body mass index : A family-based association study of eight European populations. In: European Journal of Human Genetics. 2005 ; Vol. 13, No. 4. pp. 428-434.
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AU - Bellodi, Laura

AU - Boni, Claudette

AU - Anderluh, Marija

AU - Cavallini, Maria Cristina

AU - Cellini, Elena

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AU - Erzegovesi, Stefano

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AU - Hebebrand, Johannes

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AU - Karwautz, Andreas

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AU - Nacmias, Benedetta

AU - Remschmidt, Helmut

AU - Ricca, Valdo

AU - Sorbi, Sandro

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AU - Wagner, Gudrun

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