Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations

Marta Ribasés, Mònica Gratacòs, Fernando Fernández-Aranda, Laura Bellodi, Claudette Boni, Marija Anderluh, Maria Cristina Cavallini, Elena Cellini, Daniela Di Bella, Stefano Erzegovesi, Christine Foulon, Mojca Gabrovsek, Philip Gorwood, Johannes Hebebrand, Anke Hinney, Jo Holliday, Xun Hu, Andreas Karwautz, Amélie Kipman, Radovan KomelBenedetta Nacmias, Helmut Remschmidt, Valdo Ricca, Sandro Sorbi, Gudrun Wagner, Janet Treasure, David A. Collier, Xavier P. Estivill

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Several genes with an essential role in the regulation of eating behavior and body weight are considered candidates involved in the etiology of eating disorders (ED), but no relevant susceptibility genes with a major effect on anorexia nervosa (AN) or bulimia nervosa (BN) have been identified. Brain-derived neurotrophic factor (BDNF) has been implicated in the regulation of food intake and body weight in rodents. We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients. Another single nucleotide polymorphism located in the promoter region of the BDNF gene (-270C > T) showed lack of association with any ED phenotype. In order to replicate these findings in a larger sample, we performed a case-control study in 1142 Caucasian patients with ED consecutively recruited in six different centers from five European countries (France, Germany, Italy, Spain and UK) participating in the 'Factors in Healthy Eating' project. We have found that the Met66 variant is strongly associated to all ED subtypes (AN, ANR, binge-eating/purging AN and BN), and that the -270C BDNF variant has an effect on BN and late age at onset of weight loss. These are the first two variants associated with the pathophysiology of ED in different populations and support a role for BDNF in the susceptibility to aberrant eating behaviors.

Original languageEnglish
Pages (from-to)1205-1212
Number of pages8
JournalHuman Molecular Genetics
Volume13
Issue number12
DOIs
Publication statusPublished - 15 Jun 2004
Externally publishedYes

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Bulimia
Brain-Derived Neurotrophic Factor
Anorexia
Age of Onset
Anorexia Nervosa
Weight Loss
Bulimia Nervosa
Population
Feeding Behavior
Body Weight
Appetite Regulation
Essential Genes
Genetic Promoter Regions
Spain
Italy
Genes
France
Single Nucleotide Polymorphism
Germany
Case-Control Studies

ASJC Scopus subject areas

  • Genetics

Cite this

Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. / Ribasés, Marta; Gratacòs, Mònica; Fernández-Aranda, Fernando; Bellodi, Laura; Boni, Claudette; Anderluh, Marija; Cavallini, Maria Cristina; Cellini, Elena; Di Bella, Daniela; Erzegovesi, Stefano; Foulon, Christine; Gabrovsek, Mojca; Gorwood, Philip; Hebebrand, Johannes; Hinney, Anke; Holliday, Jo; Hu, Xun; Karwautz, Andreas; Kipman, Amélie; Komel, Radovan; Nacmias, Benedetta; Remschmidt, Helmut; Ricca, Valdo; Sorbi, Sandro; Wagner, Gudrun; Treasure, Janet; Collier, David A.; Estivill, Xavier P.

In: Human Molecular Genetics, Vol. 13, No. 12, 15.06.2004, p. 1205-1212.

Research output: Contribution to journalArticle

Ribasés, M, Gratacòs, M, Fernández-Aranda, F, Bellodi, L, Boni, C, Anderluh, M, Cavallini, MC, Cellini, E, Di Bella, D, Erzegovesi, S, Foulon, C, Gabrovsek, M, Gorwood, P, Hebebrand, J, Hinney, A, Holliday, J, Hu, X, Karwautz, A, Kipman, A, Komel, R, Nacmias, B, Remschmidt, H, Ricca, V, Sorbi, S, Wagner, G, Treasure, J, Collier, DA & Estivill, XP 2004, 'Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations', Human Molecular Genetics, vol. 13, no. 12, pp. 1205-1212. https://doi.org/10.1093/hmg/ddh137
Ribasés M, Gratacòs M, Fernández-Aranda F, Bellodi L, Boni C, Anderluh M et al. Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Human Molecular Genetics. 2004 Jun 15;13(12):1205-1212. https://doi.org/10.1093/hmg/ddh137
Ribasés, Marta ; Gratacòs, Mònica ; Fernández-Aranda, Fernando ; Bellodi, Laura ; Boni, Claudette ; Anderluh, Marija ; Cavallini, Maria Cristina ; Cellini, Elena ; Di Bella, Daniela ; Erzegovesi, Stefano ; Foulon, Christine ; Gabrovsek, Mojca ; Gorwood, Philip ; Hebebrand, Johannes ; Hinney, Anke ; Holliday, Jo ; Hu, Xun ; Karwautz, Andreas ; Kipman, Amélie ; Komel, Radovan ; Nacmias, Benedetta ; Remschmidt, Helmut ; Ricca, Valdo ; Sorbi, Sandro ; Wagner, Gudrun ; Treasure, Janet ; Collier, David A. ; Estivill, Xavier P. / Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. In: Human Molecular Genetics. 2004 ; Vol. 13, No. 12. pp. 1205-1212.
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AU - Ribasés, Marta

AU - Gratacòs, Mònica

AU - Fernández-Aranda, Fernando

AU - Bellodi, Laura

AU - Boni, Claudette

AU - Anderluh, Marija

AU - Cavallini, Maria Cristina

AU - Cellini, Elena

AU - Di Bella, Daniela

AU - Erzegovesi, Stefano

AU - Foulon, Christine

AU - Gabrovsek, Mojca

AU - Gorwood, Philip

AU - Hebebrand, Johannes

AU - Hinney, Anke

AU - Holliday, Jo

AU - Hu, Xun

AU - Karwautz, Andreas

AU - Kipman, Amélie

AU - Komel, Radovan

AU - Nacmias, Benedetta

AU - Remschmidt, Helmut

AU - Ricca, Valdo

AU - Sorbi, Sandro

AU - Wagner, Gudrun

AU - Treasure, Janet

AU - Collier, David A.

AU - Estivill, Xavier P.

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