Association of ambient air pollution with the prevalence and incidence of COPD

Tamara Schikowski, Martin Adam, Alessandro Marcon, Yutong Cai, Andrea Vierkötter, Anne Elie Carsin, Benedicte Jacquemin, Zeinab Al Kanaani, Rob Beelen, Matthias Birk, Pierre Olivier Bridevaux, Bert Brunekeef, Peter Burney, Marta Cirach, Josef Cyrys, Kees De Hoogh, Roberto De Marco, Audrey De Nazelle, Christophe Declercq, Bertil ForsbergRebecca Hardy, Joachim Heinrich, Gerard Hoek, Debbie Jarvis, Dirk Keidel, Diane Kuh, Thomas Kuhlbusch, Enrica Migliore, Gioia Mosler, Mark J. Nieuwenhuijsen, Harish Phuleria, Thierry Rochat, Christian Schindler, Simona Villani, Ming Yi Tsai, Elisabeth Zemp, Anna Hansell, Francine Kauffmann, Jordi Sunyer, Nicole Probst-Hensch, Ursula Krämer, Nino Künzli

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The role of air pollution in chronic obstructive pulmonary disease (COPD) remains uncertain. The aim was to assess the impact of chronic exposure to air pollution on COPD in four cohorts using the standardised ESCAPE exposure estimates. Annual average particulate matter (PM), nitrogen oxides (NO x) and road traffic exposure were assigned to home addresses using land-use regression models. COPD was defined by NHANES reference equation (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) less than the lower limit of normal) and the Global Initiative for Chronic Obstructive Lung Disease criterion (FEV1/FVC <0.70) and categorised by severity in non-asthmatics. We included 6550 subjects with assigned NOx and 3692 with PM measures. COPD was not associated with NO2 or PM10 in any individual cohort. In meta-analyses only NO2, NOx, PM10 and the traffic indicators were positively, although not significantly, associated with COPD. The only statistically significant associations were seen in females (COPD prevalence using GOLD: OR 1.57, 95% CI 1.11-2.23; and incidence: OR 1.79, 95% CI 1.21-2.68). None of the principal results were statistically significant, the weak positive associations of exposure with COPD and the significant subgroup findings need to be evaluated in further well standardised cohorts followed up for longer time, and with time-matched exposure assignments.

Original languageEnglish
Pages (from-to)614-626
Number of pages13
JournalEuropean Respiratory Journal
Volume44
Issue number3
DOIs
Publication statusPublished - 1 Sep 2014
Externally publishedYes

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Air Pollution
Chronic Obstructive Pulmonary Disease
Incidence
Particulate Matter
Vital Capacity
Forced Expiratory Volume
Nitrogen Oxides
Nutrition Surveys
Meta-Analysis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Schikowski, T., Adam, M., Marcon, A., Cai, Y., Vierkötter, A., Carsin, A. E., ... Künzli, N. (2014). Association of ambient air pollution with the prevalence and incidence of COPD. European Respiratory Journal, 44(3), 614-626. https://doi.org/10.1183/09031936.00132213

Association of ambient air pollution with the prevalence and incidence of COPD. / Schikowski, Tamara; Adam, Martin; Marcon, Alessandro; Cai, Yutong; Vierkötter, Andrea; Carsin, Anne Elie; Jacquemin, Benedicte; Al Kanaani, Zeinab; Beelen, Rob; Birk, Matthias; Bridevaux, Pierre Olivier; Brunekeef, Bert; Burney, Peter; Cirach, Marta; Cyrys, Josef; De Hoogh, Kees; De Marco, Roberto; De Nazelle, Audrey; Declercq, Christophe; Forsberg, Bertil; Hardy, Rebecca; Heinrich, Joachim; Hoek, Gerard; Jarvis, Debbie; Keidel, Dirk; Kuh, Diane; Kuhlbusch, Thomas; Migliore, Enrica; Mosler, Gioia; Nieuwenhuijsen, Mark J.; Phuleria, Harish; Rochat, Thierry; Schindler, Christian; Villani, Simona; Tsai, Ming Yi; Zemp, Elisabeth; Hansell, Anna; Kauffmann, Francine; Sunyer, Jordi; Probst-Hensch, Nicole; Krämer, Ursula; Künzli, Nino.

In: European Respiratory Journal, Vol. 44, No. 3, 01.09.2014, p. 614-626.

Research output: Contribution to journalArticle

Schikowski, T, Adam, M, Marcon, A, Cai, Y, Vierkötter, A, Carsin, AE, Jacquemin, B, Al Kanaani, Z, Beelen, R, Birk, M, Bridevaux, PO, Brunekeef, B, Burney, P, Cirach, M, Cyrys, J, De Hoogh, K, De Marco, R, De Nazelle, A, Declercq, C, Forsberg, B, Hardy, R, Heinrich, J, Hoek, G, Jarvis, D, Keidel, D, Kuh, D, Kuhlbusch, T, Migliore, E, Mosler, G, Nieuwenhuijsen, MJ, Phuleria, H, Rochat, T, Schindler, C, Villani, S, Tsai, MY, Zemp, E, Hansell, A, Kauffmann, F, Sunyer, J, Probst-Hensch, N, Krämer, U & Künzli, N 2014, 'Association of ambient air pollution with the prevalence and incidence of COPD', European Respiratory Journal, vol. 44, no. 3, pp. 614-626. https://doi.org/10.1183/09031936.00132213
Schikowski T, Adam M, Marcon A, Cai Y, Vierkötter A, Carsin AE et al. Association of ambient air pollution with the prevalence and incidence of COPD. European Respiratory Journal. 2014 Sep 1;44(3):614-626. https://doi.org/10.1183/09031936.00132213
Schikowski, Tamara ; Adam, Martin ; Marcon, Alessandro ; Cai, Yutong ; Vierkötter, Andrea ; Carsin, Anne Elie ; Jacquemin, Benedicte ; Al Kanaani, Zeinab ; Beelen, Rob ; Birk, Matthias ; Bridevaux, Pierre Olivier ; Brunekeef, Bert ; Burney, Peter ; Cirach, Marta ; Cyrys, Josef ; De Hoogh, Kees ; De Marco, Roberto ; De Nazelle, Audrey ; Declercq, Christophe ; Forsberg, Bertil ; Hardy, Rebecca ; Heinrich, Joachim ; Hoek, Gerard ; Jarvis, Debbie ; Keidel, Dirk ; Kuh, Diane ; Kuhlbusch, Thomas ; Migliore, Enrica ; Mosler, Gioia ; Nieuwenhuijsen, Mark J. ; Phuleria, Harish ; Rochat, Thierry ; Schindler, Christian ; Villani, Simona ; Tsai, Ming Yi ; Zemp, Elisabeth ; Hansell, Anna ; Kauffmann, Francine ; Sunyer, Jordi ; Probst-Hensch, Nicole ; Krämer, Ursula ; Künzli, Nino. / Association of ambient air pollution with the prevalence and incidence of COPD. In: European Respiratory Journal. 2014 ; Vol. 44, No. 3. pp. 614-626.
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abstract = "The role of air pollution in chronic obstructive pulmonary disease (COPD) remains uncertain. The aim was to assess the impact of chronic exposure to air pollution on COPD in four cohorts using the standardised ESCAPE exposure estimates. Annual average particulate matter (PM), nitrogen oxides (NO x) and road traffic exposure were assigned to home addresses using land-use regression models. COPD was defined by NHANES reference equation (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) less than the lower limit of normal) and the Global Initiative for Chronic Obstructive Lung Disease criterion (FEV1/FVC <0.70) and categorised by severity in non-asthmatics. We included 6550 subjects with assigned NOx and 3692 with PM measures. COPD was not associated with NO2 or PM10 in any individual cohort. In meta-analyses only NO2, NOx, PM10 and the traffic indicators were positively, although not significantly, associated with COPD. The only statistically significant associations were seen in females (COPD prevalence using GOLD: OR 1.57, 95{\%} CI 1.11-2.23; and incidence: OR 1.79, 95{\%} CI 1.21-2.68). None of the principal results were statistically significant, the weak positive associations of exposure with COPD and the significant subgroup findings need to be evaluated in further well standardised cohorts followed up for longer time, and with time-matched exposure assignments.",
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AU - Marcon, Alessandro

AU - Cai, Yutong

AU - Vierkötter, Andrea

AU - Carsin, Anne Elie

AU - Jacquemin, Benedicte

AU - Al Kanaani, Zeinab

AU - Beelen, Rob

AU - Birk, Matthias

AU - Bridevaux, Pierre Olivier

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AU - Burney, Peter

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AU - Cyrys, Josef

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AU - De Marco, Roberto

AU - De Nazelle, Audrey

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AU - Hardy, Rebecca

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AU - Hoek, Gerard

AU - Jarvis, Debbie

AU - Keidel, Dirk

AU - Kuh, Diane

AU - Kuhlbusch, Thomas

AU - Migliore, Enrica

AU - Mosler, Gioia

AU - Nieuwenhuijsen, Mark J.

AU - Phuleria, Harish

AU - Rochat, Thierry

AU - Schindler, Christian

AU - Villani, Simona

AU - Tsai, Ming Yi

AU - Zemp, Elisabeth

AU - Hansell, Anna

AU - Kauffmann, Francine

AU - Sunyer, Jordi

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AU - Krämer, Ursula

AU - Künzli, Nino

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