Association of adiponectin gene polymorphism (+T45G) with acute coronary syndrome and circulating adiponectin levels

Nasser M. Rizk, Ayman El-Menyar, Isra Marei, Maha Sameer, Tasneem Musad, Dima Younis, Fathi Farag, Nora Basem, Khalid Al-Ali, Jassim Al Suwaidi

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    Abstract

    We investigated the association of adiponectin gene polymorphisms (+T45G and +G276T) and adiponectin levels with acute coronary syndrome (ACS) among Arabs in Qatar. A case-control study was performed in 142 Arab patients with ACS and 122 controls. Genotypes were determined using TaqMan real-time polymerase chain reaction assay. The TT, TG, and GG genotype frequencies of the T45G variant were significantly different among cases and controls (P =.023) but not significant for G276T genotypic frequencies. It was found that only the +45G allele was significantly associated with 3-fold increased risk of ACS (odds ratio = 2.77; 1.03-6.96; P =.043) among patients, using the genetic recessive model. Carriers of GG alleles had significantly lower adiponectin levels compared to TT/TG carriers of T45G in patients with ACS. The present study suggests that only T45G single-nucleotide polymorphism in the adiponectin gene is associated with higher odds for ACS events and has an effect on serum adiponectin levels among Arab populations.

    Original languageEnglish
    Pages (from-to)257-265
    Number of pages9
    JournalAngiology
    Volume64
    Issue number4
    DOIs
    Publication statusPublished - 1 May 2013

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    Keywords

    • acute coronary syndrome
    • adiponectin
    • gene
    • polymorphism

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Rizk, N. M., El-Menyar, A., Marei, I., Sameer, M., Musad, T., Younis, D., Farag, F., Basem, N., Al-Ali, K., & Suwaidi, J. A. (2013). Association of adiponectin gene polymorphism (+T45G) with acute coronary syndrome and circulating adiponectin levels. Angiology, 64(4), 257-265. https://doi.org/10.1177/0003319712455497