Association between RAD 51 rs1801320 and susceptibility to glioblastoma

S. Franceschi, Sara Tomei, C. M. Mazzanti, F. Lessi, P. Aretini, M. La Ferla, V. De Gregorio, F. Pasqualetti, K. Zavaglia, G. Bevilacqua, A. G. Naccarato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Glioblastoma is the most common and aggressive malignant primary brain tumor. Despite decades of research and the advent of new therapies, patients with glioblastoma continue to have a very poor prognosis. Radiation therapy has a major role as adjuvant treatment for glioblastoma following surgical resection. Many studies have shown that polymorphisms of genes involved in pathways of DNA repair may affect the sensitivity of the cells to treatment. Although the role of these polymorphisms has been investigated in relation to response to radiotherapy, their role as predisposing factors to glioblastoma has not been clarified yet. In the present study, we evaluated the association between polymorphisms in DNA repair genes, namely: XRCC1 rs25487, XRCC3 rs861539 and RAD51 rs1801320, with the susceptibility to develop glioblastoma. Eighty-five glioblastoma patients and 70 matched controls were recruited for this study. Data from the 1000 Genomes Project (98 Tuscans) were also downloaded and used for the association analysis. Subjects carrying RAD51 rs1801320 GC genotype showed an increased risk of glioblastoma (GC vs GG, χ2 = 10.75; OR 3.0087; p = 0.0010). The C allele was also significantly associated to glioblastoma (χ2 = 8.66; OR 2.5674; p = 0.0032). Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ2 = 6.558; p = 0.0053).

Original languageEnglish
Pages (from-to)265-270
Number of pages6
JournalJournal of Neuro-Oncology
Volume126
Issue number2
DOIs
Publication statusPublished - 1 Jan 2016

Fingerprint

Glioblastoma
Alleles
DNA Repair
Radiotherapy
Brain Neoplasms
Causality
Genes
Therapeutics
Genotype
Genome
Research

Keywords

  • DNA repair genes
  • Glioblastoma
  • Polymorphisms
  • RAD51
  • Risk

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Franceschi, S., Tomei, S., Mazzanti, C. M., Lessi, F., Aretini, P., La Ferla, M., ... Naccarato, A. G. (2016). Association between RAD 51 rs1801320 and susceptibility to glioblastoma. Journal of Neuro-Oncology, 126(2), 265-270. https://doi.org/10.1007/s11060-015-1974-z

Association between RAD 51 rs1801320 and susceptibility to glioblastoma. / Franceschi, S.; Tomei, Sara; Mazzanti, C. M.; Lessi, F.; Aretini, P.; La Ferla, M.; De Gregorio, V.; Pasqualetti, F.; Zavaglia, K.; Bevilacqua, G.; Naccarato, A. G.

In: Journal of Neuro-Oncology, Vol. 126, No. 2, 01.01.2016, p. 265-270.

Research output: Contribution to journalArticle

Franceschi, S, Tomei, S, Mazzanti, CM, Lessi, F, Aretini, P, La Ferla, M, De Gregorio, V, Pasqualetti, F, Zavaglia, K, Bevilacqua, G & Naccarato, AG 2016, 'Association between RAD 51 rs1801320 and susceptibility to glioblastoma', Journal of Neuro-Oncology, vol. 126, no. 2, pp. 265-270. https://doi.org/10.1007/s11060-015-1974-z
Franceschi, S. ; Tomei, Sara ; Mazzanti, C. M. ; Lessi, F. ; Aretini, P. ; La Ferla, M. ; De Gregorio, V. ; Pasqualetti, F. ; Zavaglia, K. ; Bevilacqua, G. ; Naccarato, A. G. / Association between RAD 51 rs1801320 and susceptibility to glioblastoma. In: Journal of Neuro-Oncology. 2016 ; Vol. 126, No. 2. pp. 265-270.
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