Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity

A case-control study

A. Marti, J. L. Santos, M. Gratacos, M. J. Moreno-Aliaga, A. Maiz, J. A. Martinez, Xavier P. Estivill

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction: Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis. Aim: To assess the association between human LEPR and BDNF genetic variants with adult obesity. Design and methods: Case-control study in Pamplona (Navarra, Spain) with adult obese subjects (n = 159) and normal weight controls (n = 154). Four common polymorphisms of the LEPR gene (Lys109Arg, Gln223Arg, Ser343Ser, Lys656Asn) and 17 variants of the BDNF gene, including the Val66Met variant, were genotyped. Results: No significant case-control differences were found in allele/genotype frequencies after adjusting for relevant co-variates. Haplotype analysis did not detect any significant association between LEPR or BDNF variants and obesity. No associations were found between LEPR variants and serum leptin levels. Conclusions: Our results do not support a major role of LEPR or BDNF common polymorphisms in multifactorial adult obesity.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalNutritional Neuroscience
Volume12
Issue number4
DOIs
Publication statusPublished - 1 Aug 2009
Externally publishedYes

Fingerprint

Leptin Receptors
Brain-Derived Neurotrophic Factor
Case-Control Studies
Obesity
Genes
Leptin
Gene Frequency
Spain
Haplotypes
Homeostasis
Genotype
Weights and Measures
Serum

Keywords

  • Brain-derived neurotrophic factor
  • Case-control study
  • Leptin receptor
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Neuroscience(all)

Cite this

Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity : A case-control study. / Marti, A.; Santos, J. L.; Gratacos, M.; Moreno-Aliaga, M. J.; Maiz, A.; Martinez, J. A.; Estivill, Xavier P.

In: Nutritional Neuroscience, Vol. 12, No. 4, 01.08.2009, p. 183-188.

Research output: Contribution to journalArticle

Marti, A. ; Santos, J. L. ; Gratacos, M. ; Moreno-Aliaga, M. J. ; Maiz, A. ; Martinez, J. A. ; Estivill, Xavier P. / Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity : A case-control study. In: Nutritional Neuroscience. 2009 ; Vol. 12, No. 4. pp. 183-188.
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