Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: A case-control study

A. Marti, J. L. Santos, M. Gratacos, M. J. Moreno-Aliaga, A. Maiz, J. A. Martinez, Xavier P. Estivill

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13 Citations (Scopus)


Introduction: Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis. Aim: To assess the association between human LEPR and BDNF genetic variants with adult obesity. Design and methods: Case-control study in Pamplona (Navarra, Spain) with adult obese subjects (n = 159) and normal weight controls (n = 154). Four common polymorphisms of the LEPR gene (Lys109Arg, Gln223Arg, Ser343Ser, Lys656Asn) and 17 variants of the BDNF gene, including the Val66Met variant, were genotyped. Results: No significant case-control differences were found in allele/genotype frequencies after adjusting for relevant co-variates. Haplotype analysis did not detect any significant association between LEPR or BDNF variants and obesity. No associations were found between LEPR variants and serum leptin levels. Conclusions: Our results do not support a major role of LEPR or BDNF common polymorphisms in multifactorial adult obesity.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalNutritional Neuroscience
Issue number4
Publication statusPublished - 1 Aug 2009
Externally publishedYes



  • Brain-derived neurotrophic factor
  • Case-control study
  • Leptin receptor
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Neuroscience(all)

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