The serotonin (5-HT) neurotransmitter system have been hypothesized to play a role in the etiology of psychiatric disorders. The 5HT2c receptor is a strong candidate gene to be involved in the control of body weight regulation and eating behavior. To test this hypothesis we genotyped the Cys23Ser polymorphism in the 5HT2c receptor gene in 116 patients with different eating disorders: Bulimia Nervosa (BN; n = 66), Anorexia Nervosa restricting type (ANr; n = 27) and Anorexia Nervosa purging type (ANp; n = 23), and in 59 sex-matched unrelated controls. No difference in allele frequencies of the Cys23Ser polymorphism were found between AN patients and controls (c2 = 3.1; df= 1, 2P = 0.085) or BN patients and controls (c2= 1.15; df = 1; 2P = 0.35). However, when Anorexia Nervosa restricting type patients were considered, a statistically significant difference in the 5HT2c cysteine variant with respect to controls was detected (c2 = 6.061; df=1; 2P = 0.013). These results, although preliminary, indicate that this 5HT2c gene variant may be a susceptibility factor for the Anorexia Nervosa restricting type in Spanish patients. Confirmation of these findings in a larger sample of patients and the study of cases from different geographic origins should determine the weight of the 5HT2c.
|Number of pages||2|
|Journal||American Journal of Medical Genetics - Neuropsychiatric Genetics|
|Publication status||Published - 8 Oct 2001|
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology