Association between 5HT2c and Anorexia Nervosa restricting type in Spanish patients

M. Ribasés, M. Gratacòs, A. Badia, L. Giménez, F. F. Aranda, Xavier P. Estivill

Research output: Contribution to journalArticle

Abstract

The serotonin (5-HT) neurotransmitter system have been hypothesized to play a role in the etiology of psychiatric disorders. The 5HT2c receptor is a strong candidate gene to be involved in the control of body weight regulation and eating behavior. To test this hypothesis we genotyped the Cys23Ser polymorphism in the 5HT2c receptor gene in 116 patients with different eating disorders: Bulimia Nervosa (BN; n = 66), Anorexia Nervosa restricting type (ANr; n = 27) and Anorexia Nervosa purging type (ANp; n = 23), and in 59 sex-matched unrelated controls. No difference in allele frequencies of the Cys23Ser polymorphism were found between AN patients and controls (c2 = 3.1; df= 1, 2P = 0.085) or BN patients and controls (c2= 1.15; df = 1; 2P = 0.35). However, when Anorexia Nervosa restricting type patients were considered, a statistically significant difference in the 5HT2c cysteine variant with respect to controls was detected (c2 = 6.061; df=1; 2P = 0.013). These results, although preliminary, indicate that this 5HT2c gene variant may be a susceptibility factor for the Anorexia Nervosa restricting type in Spanish patients. Confirmation of these findings in a larger sample of patients and the study of cases from different geographic origins should determine the weight of the 5HT2c.

Original languageEnglish
Pages (from-to)618-619
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume105
Issue number7
Publication statusPublished - 8 Oct 2001
Externally publishedYes

Fingerprint

Anorexia Nervosa
Serotonin
Genes
Bulimia Nervosa
Feeding Behavior
Gene Frequency
Cysteine
Neurotransmitter Agents
Psychiatry
Body Weight
Weights and Measures

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Association between 5HT2c and Anorexia Nervosa restricting type in Spanish patients. / Ribasés, M.; Gratacòs, M.; Badia, A.; Giménez, L.; Aranda, F. F.; Estivill, Xavier P.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 105, No. 7, 08.10.2001, p. 618-619.

Research output: Contribution to journalArticle

Ribasés, M. ; Gratacòs, M. ; Badia, A. ; Giménez, L. ; Aranda, F. F. ; Estivill, Xavier P. / Association between 5HT2c and Anorexia Nervosa restricting type in Spanish patients. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2001 ; Vol. 105, No. 7. pp. 618-619.
@article{01c9842faebd43d2912977aa6c8d7f31,
title = "Association between 5HT2c and Anorexia Nervosa restricting type in Spanish patients",
abstract = "The serotonin (5-HT) neurotransmitter system have been hypothesized to play a role in the etiology of psychiatric disorders. The 5HT2c receptor is a strong candidate gene to be involved in the control of body weight regulation and eating behavior. To test this hypothesis we genotyped the Cys23Ser polymorphism in the 5HT2c receptor gene in 116 patients with different eating disorders: Bulimia Nervosa (BN; n = 66), Anorexia Nervosa restricting type (ANr; n = 27) and Anorexia Nervosa purging type (ANp; n = 23), and in 59 sex-matched unrelated controls. No difference in allele frequencies of the Cys23Ser polymorphism were found between AN patients and controls (c2 = 3.1; df= 1, 2P = 0.085) or BN patients and controls (c2= 1.15; df = 1; 2P = 0.35). However, when Anorexia Nervosa restricting type patients were considered, a statistically significant difference in the 5HT2c cysteine variant with respect to controls was detected (c2 = 6.061; df=1; 2P = 0.013). These results, although preliminary, indicate that this 5HT2c gene variant may be a susceptibility factor for the Anorexia Nervosa restricting type in Spanish patients. Confirmation of these findings in a larger sample of patients and the study of cases from different geographic origins should determine the weight of the 5HT2c.",
author = "M. Ribas{\'e}s and M. Gratac{\`o}s and A. Badia and L. Gim{\'e}nez and Aranda, {F. F.} and Estivill, {Xavier P.}",
year = "2001",
month = "10",
day = "8",
language = "English",
volume = "105",
pages = "618--619",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Association between 5HT2c and Anorexia Nervosa restricting type in Spanish patients

AU - Ribasés, M.

AU - Gratacòs, M.

AU - Badia, A.

AU - Giménez, L.

AU - Aranda, F. F.

AU - Estivill, Xavier P.

PY - 2001/10/8

Y1 - 2001/10/8

N2 - The serotonin (5-HT) neurotransmitter system have been hypothesized to play a role in the etiology of psychiatric disorders. The 5HT2c receptor is a strong candidate gene to be involved in the control of body weight regulation and eating behavior. To test this hypothesis we genotyped the Cys23Ser polymorphism in the 5HT2c receptor gene in 116 patients with different eating disorders: Bulimia Nervosa (BN; n = 66), Anorexia Nervosa restricting type (ANr; n = 27) and Anorexia Nervosa purging type (ANp; n = 23), and in 59 sex-matched unrelated controls. No difference in allele frequencies of the Cys23Ser polymorphism were found between AN patients and controls (c2 = 3.1; df= 1, 2P = 0.085) or BN patients and controls (c2= 1.15; df = 1; 2P = 0.35). However, when Anorexia Nervosa restricting type patients were considered, a statistically significant difference in the 5HT2c cysteine variant with respect to controls was detected (c2 = 6.061; df=1; 2P = 0.013). These results, although preliminary, indicate that this 5HT2c gene variant may be a susceptibility factor for the Anorexia Nervosa restricting type in Spanish patients. Confirmation of these findings in a larger sample of patients and the study of cases from different geographic origins should determine the weight of the 5HT2c.

AB - The serotonin (5-HT) neurotransmitter system have been hypothesized to play a role in the etiology of psychiatric disorders. The 5HT2c receptor is a strong candidate gene to be involved in the control of body weight regulation and eating behavior. To test this hypothesis we genotyped the Cys23Ser polymorphism in the 5HT2c receptor gene in 116 patients with different eating disorders: Bulimia Nervosa (BN; n = 66), Anorexia Nervosa restricting type (ANr; n = 27) and Anorexia Nervosa purging type (ANp; n = 23), and in 59 sex-matched unrelated controls. No difference in allele frequencies of the Cys23Ser polymorphism were found between AN patients and controls (c2 = 3.1; df= 1, 2P = 0.085) or BN patients and controls (c2= 1.15; df = 1; 2P = 0.35). However, when Anorexia Nervosa restricting type patients were considered, a statistically significant difference in the 5HT2c cysteine variant with respect to controls was detected (c2 = 6.061; df=1; 2P = 0.013). These results, although preliminary, indicate that this 5HT2c gene variant may be a susceptibility factor for the Anorexia Nervosa restricting type in Spanish patients. Confirmation of these findings in a larger sample of patients and the study of cases from different geographic origins should determine the weight of the 5HT2c.

UR - http://www.scopus.com/inward/record.url?scp=33749103793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749103793&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33749103793

VL - 105

SP - 618

EP - 619

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 7

ER -