Assignment of gene responsible for progressive pseudorheumatoid dysplasia to chromosome 6 and examination of COL10A1 as candidate gene

Hatem El-Shanti, Jeffrey C. Murray, Elena V. Semina, Kenneth H. Beutow, Titia Scherpbier, Jamil Al-Alami

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17 Citations (Scopus)

Abstract

Progressive pseudorheumatoid dysplasia is an autosomal recessive skeletal dysplasia with radiographic changes in the spine similar to Spondyloepiphyseal dysplasia tarda and clinical, though not radiographic resemblance to rheumatoid arthritis. About two-thirds of the reported patients are of Arabic and Mediterranean origin which reflects the relative high incidence in this population. We performed homozygosity mapping utilising the DNA pooling approach to map progressive pseudorheumatoid dysplasia to a chromosomal region on the long arm of chromosome 6. We examined a possible candidate gene in the same region of linkage, namely COL10A1, for alterations in this disorder. We did not identify any mutations in our family, but did not totally exclude COL10A1 gene from being the disease-causing gene.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalEuropean Journal of Human Genetics
Volume6
Issue number3
Publication statusPublished - May 1998
Externally publishedYes

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Keywords

  • Collagen type X
  • Homozygosity mapping
  • Pooling
  • Pseudorheumatoid dysplasia

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

El-Shanti, H., Murray, J. C., Semina, E. V., Beutow, K. H., Scherpbier, T., & Al-Alami, J. (1998). Assignment of gene responsible for progressive pseudorheumatoid dysplasia to chromosome 6 and examination of COL10A1 as candidate gene. European Journal of Human Genetics, 6(3), 251-256.