Assessment of hyperparathyroidism

Judit Konya, Mo Aye, R. James England, Stephen Atkin

Research output: Chapter in Book/Report/Conference proceedingChapter


Parathyroid hormone (PTH) in concert with 1,25-dihydroxyvitamin D regulates the level of calcium and phosphate from skeletal, renal, and intestinal actions. Hyperparathyroidism (HPT) is a common endocrinological disease characterized by an elevated parathyroid hormone (PTH). Hyperparathyroidism can be primary (autonomous hyperfunction of one or more parathyroid glands), secondary (physiological response to hypocalcemia due to an underlying disease), or tertiary (post renal transplantation).Primary HPT may be minimally symptomatic and coincidentally found. However, the signs and symptoms of hypercalcemia include renal, neurocognitive, musculoskeletal, gastrointestinal, and cardiovascular manifestations. Differential diagnoses that should be considered include vitamin D deficiency, malignancy, familial hypocalciuric hypercalcemia, and lithium or thiazide therapy.The definitive treatment of primary HPT is parathyroidectomy; however, the clinical and biochemical features may suggest that observation alone is optimal for the patient.

Original languageEnglish
Title of host publicationTips and Tricks in Endocrine Surgery
PublisherSpringer-Verlag London Ltd
Number of pages9
ISBN (Electronic)9781447121466
ISBN (Print)9780857299826
Publication statusPublished - 1 Jan 2014
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Konya, J., Aye, M., England, R. J., & Atkin, S. (2014). Assessment of hyperparathyroidism. In Tips and Tricks in Endocrine Surgery (pp. 235-243). Springer-Verlag London Ltd.