Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index

Christian Bollensdorff, Oleg Lookin, Peter Kohl

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.

Original languageEnglish
Pages (from-to)39-48
Number of pages10
JournalPflugers Archiv European Journal of Physiology
Volume462
Issue number1
DOIs
Publication statusPublished - 1 Jul 2011
Externally publishedYes

Fingerprint

Starlings
Cardiac Myocytes
Mechanics
Guinea Pigs

Keywords

  • Cardiac mechanics
  • Heart
  • Mechanosensitivity
  • Positive inotropic response
  • Stretch

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index. / Bollensdorff, Christian; Lookin, Oleg; Kohl, Peter.

In: Pflugers Archiv European Journal of Physiology, Vol. 462, No. 1, 01.07.2011, p. 39-48.

Research output: Contribution to journalArticle

@article{9757ad4e4d264e328aafebb0924859af,
title = "Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index",
abstract = "This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.",
keywords = "Cardiac mechanics, Heart, Mechanosensitivity, Positive inotropic response, Stretch",
author = "Christian Bollensdorff and Oleg Lookin and Peter Kohl",
year = "2011",
month = "7",
day = "1",
doi = "10.1007/s00424-011-0964-z",
language = "English",
volume = "462",
pages = "39--48",
journal = "Pflugers Archiv European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index

AU - Bollensdorff, Christian

AU - Lookin, Oleg

AU - Kohl, Peter

PY - 2011/7/1

Y1 - 2011/7/1

N2 - This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.

AB - This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.

KW - Cardiac mechanics

KW - Heart

KW - Mechanosensitivity

KW - Positive inotropic response

KW - Stretch

UR - http://www.scopus.com/inward/record.url?scp=79958815977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958815977&partnerID=8YFLogxK

U2 - 10.1007/s00424-011-0964-z

DO - 10.1007/s00424-011-0964-z

M3 - Article

VL - 462

SP - 39

EP - 48

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - 1

ER -