Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index

Christian Bollensdorff, Oleg Lookin, Peter Kohl

    Research output: Contribution to journalReview article

    34 Citations (Scopus)

    Abstract

    This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.

    Original languageEnglish
    Pages (from-to)39-48
    Number of pages10
    JournalPflugers Archiv European Journal of Physiology
    Volume462
    Issue number1
    DOIs
    Publication statusPublished - 1 Jul 2011

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    Keywords

    • Cardiac mechanics
    • Heart
    • Mechanosensitivity
    • Positive inotropic response
    • Stretch

    ASJC Scopus subject areas

    • Physiology
    • Clinical Biochemistry
    • Physiology (medical)

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