Assessing corneal nerve structure and function in diabetic neuropathy

Mitra Tavakoli, Ioannis N. Petropoulos, Rayaz Malik

Research output: Contribution to journalReview article

30 Citations (Scopus)


The accurate detection and quantification of human diabetic peripheral neuropathy are important to define at-risk patients, anticipate deterioration and assess new therapies. Two emerging ophthalmic techniques, namely, corneal confocal microscopy and corneal aesthesiometry, demonstrate the ability to diagnose, quantify severity and assess therapeutic benefit in diabetic peripheral neuropathy. Corneal confocal microscopy allows quantification of corneal nerve morphology and non-contact corneal aesthesiometry assesses corneal sensitivity. The present review provides a detailed critique of the rationale, practical application in terms of the instruments used to capture images and the basis on which images are interpreted and analysed. We also critically evaluate how these two new non-invasive ophthalmic tests can be deployed to diagnose diabetic and other peripheral neuropathies.

Original languageEnglish
Pages (from-to)338-347
Number of pages10
JournalClinical and Experimental Optometry
Issue number3
Publication statusPublished - May 2012
Externally publishedYes



  • Cornea
  • Corneal nerves
  • Diabetes
  • Diabetic neuropathy
  • In vivo corneal confocal microscopy (IVCCM)

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

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