Array-based pharmacogenomics of molecular-targeted therapies in oncology

D. Sanoudou, G. Mountzios, D. A. Arvanitis, D. Pectasides

    Research output: Contribution to journalReview article

    9 Citations (Scopus)

    Abstract

    The advent of microarrays over the past decade has transformed the way genome-wide studies are designed and conducted, leading to an unprecedented speed of acquisition and amount of new knowledge. Microarray data have led to the identification of molecular subclasses of solid tumors characterized by distinct oncogenic pathways, as well as the development of multigene prognostic or predictive models equivalent or superior to those of established clinical parameters. In the field of molecular-targeted therapy for cancer, in particular, the application of array-based methodologies has enabled the identification of molecular targets with 'key' roles in neoplastic transformation or tumor progression and the subsequent development of targeted agents, which are most likely to be active in the specific molecular setting. Herein, we present a summary of the main applications of whole-genome expression microarrays in the field of molecular-targeted therapies for solid tumors and we discuss their potential in the clinical setting. An emphasis is given on deciphering the molecular mechanisms of drug action, identifying novel therapeutic targets and suitable agents to target them with, and discovering molecular markers/signatures that predict response to therapy or optimal drug dose for each patient.

    Original languageEnglish
    Pages (from-to)185-196
    Number of pages12
    JournalPharmacogenomics Journal
    Volume12
    Issue number3
    DOIs
    Publication statusPublished - 1 Jun 2012

    Keywords

    • cetuximab
    • erlotinib
    • gefitinib
    • molecular-targeted agents
    • trastuzumab

    ASJC Scopus subject areas

    • Molecular Medicine
    • Genetics
    • Pharmacology

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  • Cite this

    Sanoudou, D., Mountzios, G., Arvanitis, D. A., & Pectasides, D. (2012). Array-based pharmacogenomics of molecular-targeted therapies in oncology. Pharmacogenomics Journal, 12(3), 185-196. https://doi.org/10.1038/tpj.2011.53