Applying genetic strategies to prevent atherosclerosis

Roger R. Williams, Paul N. Hopkins, Lily L. Wu, Steven Hunt

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Atherosclerotic disease of coronary and cerebral arteries accounts for almost half of all deaths in the United States each year. Heart attacks and strokes are often attributable to inherited predisposition, especially when they occur at a relatively early age. Researchers are accumulating information regarding the role of genetics in influencing the risk factors for atherosclerosis in several major categories, including lipids and lipoproteins (LDL HDL and VLDL cholesterol; Lp(a); triglycerides; apo ALAII, and B; apo E genotypes); glucose and insulin metabolism (diabetes, glucose intolerance, and insulin resistance); prothrombotic factors (fibrinogen, plasminogen activator inhibitor-1, factor VII coagulant activity, homocysteine); and hypertension. This chapter discusses the basic approaches for evaluating and addressing heritable factors for atherosclerosis.

Original languageEnglish
Title of host publicationGenetics and Public Health in the 21st Century: Using Genetic Information to Improve Health and Prevent Disease
PublisherOxford University Press
ISBN (Electronic)9780199864485
ISBN (Print)9780195128307
DOIs
Publication statusPublished - 1 Sep 2009
Externally publishedYes

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Keywords

  • Atherosclerotic disease
  • Genetic factors
  • Heart disease
  • Public health
  • Strokes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Williams, R. R., Hopkins, P. N., Wu, L. L., & Hunt, S. (2009). Applying genetic strategies to prevent atherosclerosis. In Genetics and Public Health in the 21st Century: Using Genetic Information to Improve Health and Prevent Disease Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195128307.003.0024