Application of nanomagnetic particles in hyperthermia cancer treatment

S. Hayek, C. J. Chen, Y. Haik, V. Mohite

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This research focuses on developing uniform particles with a Curie temperature that is similar to the therapeutic one for the purpose of cancer treatment. Such particles will self-regulate the temperature of the tumor during magnetic hyperthermia (MH), thus avoiding the use of temperature controls. MH is based on a defined transfer of power onto magnetic nanoparticles in an alternate magnetic field that is determined by the frequency, magnetic field's strength, materials and the size of the particles, which result in localized generation of heat. This heat will either destroy the tumor cells directly or results in a synergic reinforcement of radiation efficacy, depending on the equilibrium temperature set in the tumor tissue. MH involves the local deposition of tumor cell specific magnetic nanoparticles and an external alternating current magnetic field applicator system. Nanoferrite particles can be easily applied interstitially for minimum invasive application. In this study more uniform nanoparticles have been manufactured and they were tested for their Curie temperature for self-regulated MH. Materials which have been investigated for such procedure are Gd-Zn ferrite, MnZnFe2O 4 and La3/4Sr1/4MnO3 and many others. Finally, the concept of discrete magnetic heating is addressed.

Original languageEnglish
Title of host publication2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages67-70
Number of pages4
Publication statusPublished - 8 Dec 2006
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: 7 May 200611 May 2006

Publication series

Name2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Volume2

Other

Other2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
CountryUnited States
CityBoston, MA
Period7/5/0611/5/06

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Keywords

  • Ac magnetic field
  • Curie temperature
  • Magnetic hyperthermia
  • Magnetic nanoparticles
  • Pulsed magnetic field

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hayek, S., Chen, C. J., Haik, Y., & Mohite, V. (2006). Application of nanomagnetic particles in hyperthermia cancer treatment. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings (pp. 67-70). (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings; Vol. 2).