APOH interacts with FTO to predispose to healthy thinness

Sandra J. Hasstedt, Hilary Coon, Yuanpei Xin, Ted D. Adams, Steven Hunt

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We identified eight candidate thinness predisposition variants from the Illumina HumanExome chip genotyped on members of pedigrees selected for either healthy thinness or severe obesity. For validation, we tested the candidates for association with healthy thinness in additional pedigree members while accounting for effects of obesity-associated genes: NPFFR2, NPY2R, FTO, and MC4R. Significance was obtained for the interaction of FTO rs9939609 with APOH missense variant rs52797880 (minor allele frequency 0.054). The thinness odds ratio was estimated as 2.15 (p < 0.05) for the combination of APOH heterozygote with the homozygote for the non-obesity FTO allele. Significance was not obtained for any other combination of a candidate variant with an obesity gene or for any of the eight candidates tested independently.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalHuman Genetics
Volume135
Issue number2
DOIs
Publication statusPublished - 1 Feb 2016

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Thinness
Pedigree
Obesity
Morbid Obesity
Homozygote
Heterozygote
Gene Frequency
Genes
Alleles
Odds Ratio

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

APOH interacts with FTO to predispose to healthy thinness. / Hasstedt, Sandra J.; Coon, Hilary; Xin, Yuanpei; Adams, Ted D.; Hunt, Steven.

In: Human Genetics, Vol. 135, No. 2, 01.02.2016, p. 201-207.

Research output: Contribution to journalArticle

Hasstedt, SJ, Coon, H, Xin, Y, Adams, TD & Hunt, S 2016, ' APOH interacts with FTO to predispose to healthy thinness', Human Genetics, vol. 135, no. 2, pp. 201-207. https://doi.org/10.1007/s00439-015-1629-3
Hasstedt, Sandra J. ; Coon, Hilary ; Xin, Yuanpei ; Adams, Ted D. ; Hunt, Steven. / APOH interacts with FTO to predispose to healthy thinness. In: Human Genetics. 2016 ; Vol. 135, No. 2. pp. 201-207.
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