Antiproteases and antioxidants: Strategies for the pharmacologic prevention of lung destruction

Richard C. Hubbard, Ronald Crystal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Proteolysis and oxidation are processes which play a central role in the pathogenesis of emphysema. Hereditary factors, including α1-antitrypsin deficiency, and environmental exposures, such as to cigarette smoke, coal dust and bacteria, are associated with a high risk for the development of emphysema through their interactions with proteolytic and oxidative processes within the lung. Because of the key roles of oxidation and proteolysis, reasonable strategies for the prevention of lung destruction in high-risk individuals include such therapeutic interventions as augmentation of lung levels of α-antitrypsin and the administration of antioxidants.

Original languageEnglish
Pages (from-to)56-73
Number of pages18
JournalRespiration
Volume50
DOIs
Publication statusPublished - 1 Jan 1986
Externally publishedYes

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Keywords

  • Antioxidants
  • Antiproteases
  • ArAntitrypsin
  • Coal dust
  • Emphysema
  • Etiology
  • Gene therapy
  • Oxidants
  • Proteases
  • Pseudomnnas
  • Smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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