Anti-Leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from tibouchina paratropica

María I. Tracanna, Antonio M. Fortuna, Angel V. Contreras Cárdenas, Alexandra K. Marr, W. Robert McMaster, Anaximandro Gõmez-Velasco, Eugenio Sánchez-Arreola, Luis Ricardo Hernández, Horacio Bach

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and compound 1 displayed potent anti-parasitic activity against Leishmania donovani (IC50 = 0.809 μg/mL). In addition, an 85% reduction in the secretion of the pro-inflammatory cytokine IL-6 was recorded when macrophages challenged with lipopolysaccharide were exposed to compound 1, but no effect on the anti-inflammatory IL-10 was observed. Compound 2 showed neither anti-parasitic nor anti-inflammatory properties. In addition, no cytotoxic activities were observed against the human-derived macrophage THP-1 cells.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalPhytotherapy Research
Volume29
Issue number3
DOIs
Publication statusPublished - 2015
Externally publishedYes

Fingerprint

Anti-Inflammatory Agents
Macrophages
Leishmania donovani
Interleukin-10
Inhibitory Concentration 50
Lipopolysaccharides
Interleukin-6
Cytokines
isoquercitrin
2,8-dihydroxy-7H-furo(2,3-f)chromen-7-one

Keywords

  • bioactivities
  • Melastomataceae
  • phenolic derivatives
  • Tibouchina paratropica

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Tracanna, M. I., Fortuna, A. M., Contreras Cárdenas, A. V., Marr, A. K., McMaster, W. R., Gõmez-Velasco, A., ... Bach, H. (2015). Anti-Leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from tibouchina paratropica. Phytotherapy Research, 29(3), 393-397. https://doi.org/10.1002/ptr.5263

Anti-Leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from tibouchina paratropica. / Tracanna, María I.; Fortuna, Antonio M.; Contreras Cárdenas, Angel V.; Marr, Alexandra K.; McMaster, W. Robert; Gõmez-Velasco, Anaximandro; Sánchez-Arreola, Eugenio; Hernández, Luis Ricardo; Bach, Horacio.

In: Phytotherapy Research, Vol. 29, No. 3, 2015, p. 393-397.

Research output: Contribution to journalArticle

Tracanna, MI, Fortuna, AM, Contreras Cárdenas, AV, Marr, AK, McMaster, WR, Gõmez-Velasco, A, Sánchez-Arreola, E, Hernández, LR & Bach, H 2015, 'Anti-Leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from tibouchina paratropica', Phytotherapy Research, vol. 29, no. 3, pp. 393-397. https://doi.org/10.1002/ptr.5263
Tracanna, María I. ; Fortuna, Antonio M. ; Contreras Cárdenas, Angel V. ; Marr, Alexandra K. ; McMaster, W. Robert ; Gõmez-Velasco, Anaximandro ; Sánchez-Arreola, Eugenio ; Hernández, Luis Ricardo ; Bach, Horacio. / Anti-Leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from tibouchina paratropica. In: Phytotherapy Research. 2015 ; Vol. 29, No. 3. pp. 393-397.
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