Anti-inflammatory effects of resolvins in diabetic nephropathy

Mechanistic pathways

Habib Yaribeygi, Stephen Atkin, Luis E. Simental-Mendía, George E. Barreto, Amirhossein Sahebkar

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. The pathways by which resolvins exert this anti-inflammatory effect are unclear. In this review we discuss the evidence showing that resolvins can suppress inflammatory responses via at least five molecular mechanisms through inhibition of the nucleotide-binding oligomerization domain protein 3 inflammasome, inhibition of nuclear factor κB molecular pathways, improvement of oxidative stress, modulation of nitric oxide synthesis/release and prevention of local and systemic leukocytosis. Complete understanding of these molecular pathways is important as this may lead to the development of new effective therapeutic strategies for diabetes and diabetic nephropathy.

Original languageEnglish
JournalJournal of Cellular Physiology
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Diabetic Nephropathies
Medical problems
Nod Signaling Adaptor Proteins
Anti-Inflammatory Agents
Inflammasomes
Seafood
Fish Oils
Leukocytosis
Unsaturated Fatty Acids
Diabetes Mellitus
Nitric Oxide
Oxidative Stress
Kidney
Oligomerization
Oxidative stress
Incidence
Nucleotides
Modulation
Tissue
Therapeutics

Keywords

  • diabetic nephropathy
  • inflammation
  • NF-κB
  • oxidative stress
  • resolvin D1
  • resolvin E1

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Anti-inflammatory effects of resolvins in diabetic nephropathy : Mechanistic pathways. / Yaribeygi, Habib; Atkin, Stephen; Simental-Mendía, Luis E.; Barreto, George E.; Sahebkar, Amirhossein.

In: Journal of Cellular Physiology, 01.01.2019.

Research output: Contribution to journalReview article

Yaribeygi, Habib ; Atkin, Stephen ; Simental-Mendía, Luis E. ; Barreto, George E. ; Sahebkar, Amirhossein. / Anti-inflammatory effects of resolvins in diabetic nephropathy : Mechanistic pathways. In: Journal of Cellular Physiology. 2019.
@article{59bffeae20824f519aa4aaad757e78e3,
title = "Anti-inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways",
abstract = "The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. The pathways by which resolvins exert this anti-inflammatory effect are unclear. In this review we discuss the evidence showing that resolvins can suppress inflammatory responses via at least five molecular mechanisms through inhibition of the nucleotide-binding oligomerization domain protein 3 inflammasome, inhibition of nuclear factor κB molecular pathways, improvement of oxidative stress, modulation of nitric oxide synthesis/release and prevention of local and systemic leukocytosis. Complete understanding of these molecular pathways is important as this may lead to the development of new effective therapeutic strategies for diabetes and diabetic nephropathy.",
keywords = "diabetic nephropathy, inflammation, NF-κB, oxidative stress, resolvin D1, resolvin E1",
author = "Habib Yaribeygi and Stephen Atkin and Simental-Mend{\'i}a, {Luis E.} and Barreto, {George E.} and Amirhossein Sahebkar",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/jcp.28315",
language = "English",
journal = "Journal of Cellular Physiology",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Anti-inflammatory effects of resolvins in diabetic nephropathy

T2 - Mechanistic pathways

AU - Yaribeygi, Habib

AU - Atkin, Stephen

AU - Simental-Mendía, Luis E.

AU - Barreto, George E.

AU - Sahebkar, Amirhossein

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. The pathways by which resolvins exert this anti-inflammatory effect are unclear. In this review we discuss the evidence showing that resolvins can suppress inflammatory responses via at least five molecular mechanisms through inhibition of the nucleotide-binding oligomerization domain protein 3 inflammasome, inhibition of nuclear factor κB molecular pathways, improvement of oxidative stress, modulation of nitric oxide synthesis/release and prevention of local and systemic leukocytosis. Complete understanding of these molecular pathways is important as this may lead to the development of new effective therapeutic strategies for diabetes and diabetic nephropathy.

AB - The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. The pathways by which resolvins exert this anti-inflammatory effect are unclear. In this review we discuss the evidence showing that resolvins can suppress inflammatory responses via at least five molecular mechanisms through inhibition of the nucleotide-binding oligomerization domain protein 3 inflammasome, inhibition of nuclear factor κB molecular pathways, improvement of oxidative stress, modulation of nitric oxide synthesis/release and prevention of local and systemic leukocytosis. Complete understanding of these molecular pathways is important as this may lead to the development of new effective therapeutic strategies for diabetes and diabetic nephropathy.

KW - diabetic nephropathy

KW - inflammation

KW - NF-κB

KW - oxidative stress

KW - resolvin D1

KW - resolvin E1

UR - http://www.scopus.com/inward/record.url?scp=85061430817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061430817&partnerID=8YFLogxK

U2 - 10.1002/jcp.28315

DO - 10.1002/jcp.28315

M3 - Review article

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

SN - 0021-9541

ER -