Anti-Ia antibody eluted from rejected human renal allografts

M. R. Garovoy, Manikkam Suthanthiran, P. Gailiunas, C. B. Carpenter, M. Graves, G. Busch, N. L. Tilney

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Additional evidence has been gathered that anti-Ia antibody may be an important component in graft presensitization as well as a useful correlate of rejection activity. Finding anti-Ia antibody positive for EAI in 8/9 eluates from rejected kidneys supports a pathogenetic role for these antibodies. The recent demonstration of Ia antigens on vascular endothelium, together with the evidence of severe vascular injury in our rejected grafts, provides additional corroboration for the hypothesis that anti-Ia antibodies are instrumental in producing the vascular lesions characteristic of humoral rejection. Thus, in addition to direct cell-mediated injury, anti-HLA antibodies of A, B and C locus specificity and anti-Ia antibodies may also act to further graft injury through pathways of complement-dependent lysis and cellular activation.

Original languageEnglish
Pages (from-to)613-616
Number of pages4
JournalTransplantation Proceedings
Volume10
Issue number3
Publication statusPublished - 1 Dec 1978
Externally publishedYes

Fingerprint

Allografts
Anti-Idiotypic Antibodies
Kidney
Transplants
HLA-C Antigens
Vascular System Injuries
Histocompatibility Antigens Class II
Vascular Endothelium
Wounds and Injuries
Blood Vessels
Antibodies

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Garovoy, M. R., Suthanthiran, M., Gailiunas, P., Carpenter, C. B., Graves, M., Busch, G., & Tilney, N. L. (1978). Anti-Ia antibody eluted from rejected human renal allografts. Transplantation Proceedings, 10(3), 613-616.

Anti-Ia antibody eluted from rejected human renal allografts. / Garovoy, M. R.; Suthanthiran, Manikkam; Gailiunas, P.; Carpenter, C. B.; Graves, M.; Busch, G.; Tilney, N. L.

In: Transplantation Proceedings, Vol. 10, No. 3, 01.12.1978, p. 613-616.

Research output: Contribution to journalArticle

Garovoy, MR, Suthanthiran, M, Gailiunas, P, Carpenter, CB, Graves, M, Busch, G & Tilney, NL 1978, 'Anti-Ia antibody eluted from rejected human renal allografts', Transplantation Proceedings, vol. 10, no. 3, pp. 613-616.
Garovoy MR, Suthanthiran M, Gailiunas P, Carpenter CB, Graves M, Busch G et al. Anti-Ia antibody eluted from rejected human renal allografts. Transplantation Proceedings. 1978 Dec 1;10(3):613-616.
Garovoy, M. R. ; Suthanthiran, Manikkam ; Gailiunas, P. ; Carpenter, C. B. ; Graves, M. ; Busch, G. ; Tilney, N. L. / Anti-Ia antibody eluted from rejected human renal allografts. In: Transplantation Proceedings. 1978 ; Vol. 10, No. 3. pp. 613-616.
@article{d28f7e5543cc413da0ba44b1e2f138f8,
title = "Anti-Ia antibody eluted from rejected human renal allografts",
abstract = "Additional evidence has been gathered that anti-Ia antibody may be an important component in graft presensitization as well as a useful correlate of rejection activity. Finding anti-Ia antibody positive for EAI in 8/9 eluates from rejected kidneys supports a pathogenetic role for these antibodies. The recent demonstration of Ia antigens on vascular endothelium, together with the evidence of severe vascular injury in our rejected grafts, provides additional corroboration for the hypothesis that anti-Ia antibodies are instrumental in producing the vascular lesions characteristic of humoral rejection. Thus, in addition to direct cell-mediated injury, anti-HLA antibodies of A, B and C locus specificity and anti-Ia antibodies may also act to further graft injury through pathways of complement-dependent lysis and cellular activation.",
author = "Garovoy, {M. R.} and Manikkam Suthanthiran and P. Gailiunas and Carpenter, {C. B.} and M. Graves and G. Busch and Tilney, {N. L.}",
year = "1978",
month = "12",
day = "1",
language = "English",
volume = "10",
pages = "613--616",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Anti-Ia antibody eluted from rejected human renal allografts

AU - Garovoy, M. R.

AU - Suthanthiran, Manikkam

AU - Gailiunas, P.

AU - Carpenter, C. B.

AU - Graves, M.

AU - Busch, G.

AU - Tilney, N. L.

PY - 1978/12/1

Y1 - 1978/12/1

N2 - Additional evidence has been gathered that anti-Ia antibody may be an important component in graft presensitization as well as a useful correlate of rejection activity. Finding anti-Ia antibody positive for EAI in 8/9 eluates from rejected kidneys supports a pathogenetic role for these antibodies. The recent demonstration of Ia antigens on vascular endothelium, together with the evidence of severe vascular injury in our rejected grafts, provides additional corroboration for the hypothesis that anti-Ia antibodies are instrumental in producing the vascular lesions characteristic of humoral rejection. Thus, in addition to direct cell-mediated injury, anti-HLA antibodies of A, B and C locus specificity and anti-Ia antibodies may also act to further graft injury through pathways of complement-dependent lysis and cellular activation.

AB - Additional evidence has been gathered that anti-Ia antibody may be an important component in graft presensitization as well as a useful correlate of rejection activity. Finding anti-Ia antibody positive for EAI in 8/9 eluates from rejected kidneys supports a pathogenetic role for these antibodies. The recent demonstration of Ia antigens on vascular endothelium, together with the evidence of severe vascular injury in our rejected grafts, provides additional corroboration for the hypothesis that anti-Ia antibodies are instrumental in producing the vascular lesions characteristic of humoral rejection. Thus, in addition to direct cell-mediated injury, anti-HLA antibodies of A, B and C locus specificity and anti-Ia antibodies may also act to further graft injury through pathways of complement-dependent lysis and cellular activation.

UR - http://www.scopus.com/inward/record.url?scp=0018159592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018159592&partnerID=8YFLogxK

M3 - Article

C2 - 362645

AN - SCOPUS:0018159592

VL - 10

SP - 613

EP - 616

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 3

ER -