Anti-cancer drugs interfere with intracellular calcium signaling

Ana Maria Florea, Dietrich Busselberg

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

(Neuro-)toxicity of metal and metal compounds is frequently highlighted. While specific metals or metal compounds are essential for cellular function, other metals are toxic and/or carcinogens. Metals can trigger accidental cell death in the form of necrosis, or activate programmed cell death in the form of apoptosis. The aim of anti-cancer therapy is induction of apoptosis in tumor cells. Therefore, there is an interesting twist in the toxicity of metals and metal compounds (e.g., arsenic trioxide, cisplatin); since they have a higher specificity to induce apoptosis in cancer cells (possibly due to the high turnover in these cells) they are used to cure some forms of cancer. A body of evidence suggests that second messengers, such as modulations in the intracellular calcium concentration, could be involved in metals induced toxicity as well as in the beneficial effects shown by anti-cancer drugs. Here we review the influence on calcium homeostasis induced by some metallic compounds: cisplatin, arsenic trioxide and trimethyltin chloride.

Original languageEnglish
Pages (from-to)803-810
Number of pages8
JournalNeuroToxicology
Volume30
Issue number5
DOIs
Publication statusPublished - Sep 2009
Externally publishedYes

Fingerprint

Calcium Signaling
Metals
Calcium
Pharmaceutical Preparations
Neoplasms
Toxicity
Cell death
Apoptosis
Cisplatin
Cell Death
Cells
Metallic compounds
Poisons
Second Messenger Systems
Carcinogens
Tumors
Homeostasis
Necrosis
Modulation

Keywords

  • Anti-cancer treatment
  • Arsenic trioxide
  • Calcium homeostasis
  • Cisplatin
  • Co-application
  • Intracelluar calcium signaling
  • Trimethyltin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Anti-cancer drugs interfere with intracellular calcium signaling. / Florea, Ana Maria; Busselberg, Dietrich.

In: NeuroToxicology, Vol. 30, No. 5, 09.2009, p. 803-810.

Research output: Contribution to journalReview article

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