Angiocrine endothelium: From physiology to cancer

Jennifer Pasquier, Pegah Ghiabi, Lotfi Chouchane, Kais Razzouk, Shahin Rafii, Arash Rafii

Research output: Contribution to journalReview article

Abstract

The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothelial cells (ECs) in this scenario was initially attributed to their role in vasculogenesis and angiogenesis that is critical for tumor initiation and growth. Nevertheless, the identification of endothelial-derived angiocrine factors illustrated an alternative non-angiogenic function of ECs contributing to both physiological and pathological tissue development. Gene expression profiling studies have demonstrated distinctive expression patterns in tumor-associated endothelial cells that imply a bilateral crosstalk between tumor and its endothelium. Recently, some of the molecular determinants of this reciprocal interaction have been identified which are considered as potential targets for developing novel anti-angiocrine therapeutic strategies.

Original languageEnglish
Article number52
JournalJournal of translational medicine
Volume18
Issue number1
DOIs
Publication statusPublished - 3 Feb 2020

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Keywords

  • Angiocrine
  • Angiogenesis
  • Cancer
  • Cancer microenvironment
  • Endothelium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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