Anchoring fibrils in the normal canine respiratory system

O. Kawanami, V. J. Ferrans, Ronald Crystal

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Electron microscopic study of the normal canine respiratory tree disclosed the presence of anchoring fibrils, a distinct class of fibrils of extracellular connective tissue, in association with the following types of cells: basal cells and special type cells of trachea and bronchi; ciliated cells and basal cells of bronchioles; ductal cells, secretory cells, and myoepithelial cells of tracheobronchial glands. Anchoring fibrils in the normal respiratory system measured up to 6,000 Å in length and from 170 to 400 Å in thickness, and had a banding pattern that differed from that of collagen fibrils and connective tissue microfibrils. They formed arcs, the ends of which inserted into the basal lamina underlying the basal portions of the cells, often in the vicinity of hemidesmosomes. Anchoring fibrils decreased in number and size in the more distal portions of the respiratory tree, and were not found in alveolar septums. Anchoring fibrils in lung appeared similar to those described in other organs, but were often small and inconspicuous. The function of these structures is to reinforce the attachment of the epithelial basal lamina to the underyling connective tissues.

Original languageEnglish
Pages (from-to)595-611
Number of pages17
JournalAmerican Review of Respiratory Disease
Volume120
Issue number3
Publication statusPublished - 1 Dec 1979
Externally publishedYes

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Respiratory System
Canidae
Connective Tissue
Basement Membrane
Epithelial Attachment
Hemidesmosomes
Microfibrils
Bronchioles
Bronchi
Trachea
Collagen
Electrons
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Anchoring fibrils in the normal canine respiratory system. / Kawanami, O.; Ferrans, V. J.; Crystal, Ronald.

In: American Review of Respiratory Disease, Vol. 120, No. 3, 01.12.1979, p. 595-611.

Research output: Contribution to journalArticle

Kawanami, O. ; Ferrans, V. J. ; Crystal, Ronald. / Anchoring fibrils in the normal canine respiratory system. In: American Review of Respiratory Disease. 1979 ; Vol. 120, No. 3. pp. 595-611.
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