Análisis de las regiones de predisposición a la psoriasis en la población Española

Evidencia de un gen principal implicado en la psoriasis en la regiõn 6p21

Translated title of the contribution: Analysis of the susceptibility regions to psoriasis in Spanish population: Evidence of a major gene involved in psoriasis in 6p21

Rafael De Cid, Víctor Volpini, Laura Almasy, David Otero, Xavier P. Estivill, Conxi Lázaro, E. Barberà, C. Ferrándiz, A. Giménez Arnau, F. Grimalt, S. Puig, A. Sánchez, A. Palacios, J. A. Pujol, M. Sánchez, E. Simal, F. Vázquez, B. Ramírez

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Identification of the susceptibility regions to psoriasis in Spanish population. Analysis of the chromosomal regions 6p, 17q, 4q and 1cen-q21. PATIENTS AND METHOD: Analysis of 27 Spanish families with psoriasis. Parametric and non-parametric linkage analysis with 22 polymorphic microsatellite markers in the candidate regions. RESULTS: Evidence of linkage (p < 0,05) using non-parametric methods in chromosome 6p. Absence of linkage in 17q, 4q and 1cen-q21 regions. CONCLUSION: We present the evidence of a major gene in 6p21.3 involved in psoriasis in Spanish population.

Original languageSpanish
Pages (from-to)49-51
Number of pages3
JournalMedicina Clinica
Volume117
Issue number2
Publication statusPublished - 16 Jun 2001
Externally publishedYes

Fingerprint

Psoriasis
Population
Genes
Microsatellite Repeats
Chromosomes

Keywords

  • Candidate genes
  • Genetic linkage
  • Psoriasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Análisis de las regiones de predisposición a la psoriasis en la población Española : Evidencia de un gen principal implicado en la psoriasis en la regiõn 6p21. / De Cid, Rafael; Volpini, Víctor; Almasy, Laura; Otero, David; Estivill, Xavier P.; Lázaro, Conxi; Barberà, E.; Ferrándiz, C.; Arnau, A. Giménez; Grimalt, F.; Puig, S.; Sánchez, A.; Palacios, A.; Pujol, J. A.; Sánchez, M.; Simal, E.; Vázquez, F.; Ramírez, B.

In: Medicina Clinica, Vol. 117, No. 2, 16.06.2001, p. 49-51.

Research output: Contribution to journalArticle

De Cid, R, Volpini, V, Almasy, L, Otero, D, Estivill, XP, Lázaro, C, Barberà, E, Ferrándiz, C, Arnau, AG, Grimalt, F, Puig, S, Sánchez, A, Palacios, A, Pujol, JA, Sánchez, M, Simal, E, Vázquez, F & Ramírez, B 2001, 'Análisis de las regiones de predisposición a la psoriasis en la población Española: Evidencia de un gen principal implicado en la psoriasis en la regiõn 6p21', Medicina Clinica, vol. 117, no. 2, pp. 49-51.
De Cid, Rafael ; Volpini, Víctor ; Almasy, Laura ; Otero, David ; Estivill, Xavier P. ; Lázaro, Conxi ; Barberà, E. ; Ferrándiz, C. ; Arnau, A. Giménez ; Grimalt, F. ; Puig, S. ; Sánchez, A. ; Palacios, A. ; Pujol, J. A. ; Sánchez, M. ; Simal, E. ; Vázquez, F. ; Ramírez, B. / Análisis de las regiones de predisposición a la psoriasis en la población Española : Evidencia de un gen principal implicado en la psoriasis en la regiõn 6p21. In: Medicina Clinica. 2001 ; Vol. 117, No. 2. pp. 49-51.
@article{e43c61f5400f40eaa60d73fae8cf6dbe,
title = "An{\'a}lisis de las regiones de predisposici{\'o}n a la psoriasis en la poblaci{\'o}n Espa{\~n}ola: Evidencia de un gen principal implicado en la psoriasis en la regi{\~o}n 6p21",
abstract = "BACKGROUND: Identification of the susceptibility regions to psoriasis in Spanish population. Analysis of the chromosomal regions 6p, 17q, 4q and 1cen-q21. PATIENTS AND METHOD: Analysis of 27 Spanish families with psoriasis. Parametric and non-parametric linkage analysis with 22 polymorphic microsatellite markers in the candidate regions. RESULTS: Evidence of linkage (p < 0,05) using non-parametric methods in chromosome 6p. Absence of linkage in 17q, 4q and 1cen-q21 regions. CONCLUSION: We present the evidence of a major gene in 6p21.3 involved in psoriasis in Spanish population.",
keywords = "Candidate genes, Genetic linkage, Psoriasis",
author = "{De Cid}, Rafael and V{\'i}ctor Volpini and Laura Almasy and David Otero and Estivill, {Xavier P.} and Conxi L{\'a}zaro and E. Barber{\`a} and C. Ferr{\'a}ndiz and Arnau, {A. Gim{\'e}nez} and F. Grimalt and S. Puig and A. S{\'a}nchez and A. Palacios and Pujol, {J. A.} and M. S{\'a}nchez and E. Simal and F. V{\'a}zquez and B. Ram{\'i}rez",
year = "2001",
month = "6",
day = "16",
language = "Spanish",
volume = "117",
pages = "49--51",
journal = "Medicina Clinica",
issn = "0025-7753",
publisher = "Ediciones Doyma, S.L.",
number = "2",

}

TY - JOUR

T1 - Análisis de las regiones de predisposición a la psoriasis en la población Española

T2 - Evidencia de un gen principal implicado en la psoriasis en la regiõn 6p21

AU - De Cid, Rafael

AU - Volpini, Víctor

AU - Almasy, Laura

AU - Otero, David

AU - Estivill, Xavier P.

AU - Lázaro, Conxi

AU - Barberà, E.

AU - Ferrándiz, C.

AU - Arnau, A. Giménez

AU - Grimalt, F.

AU - Puig, S.

AU - Sánchez, A.

AU - Palacios, A.

AU - Pujol, J. A.

AU - Sánchez, M.

AU - Simal, E.

AU - Vázquez, F.

AU - Ramírez, B.

PY - 2001/6/16

Y1 - 2001/6/16

N2 - BACKGROUND: Identification of the susceptibility regions to psoriasis in Spanish population. Analysis of the chromosomal regions 6p, 17q, 4q and 1cen-q21. PATIENTS AND METHOD: Analysis of 27 Spanish families with psoriasis. Parametric and non-parametric linkage analysis with 22 polymorphic microsatellite markers in the candidate regions. RESULTS: Evidence of linkage (p < 0,05) using non-parametric methods in chromosome 6p. Absence of linkage in 17q, 4q and 1cen-q21 regions. CONCLUSION: We present the evidence of a major gene in 6p21.3 involved in psoriasis in Spanish population.

AB - BACKGROUND: Identification of the susceptibility regions to psoriasis in Spanish population. Analysis of the chromosomal regions 6p, 17q, 4q and 1cen-q21. PATIENTS AND METHOD: Analysis of 27 Spanish families with psoriasis. Parametric and non-parametric linkage analysis with 22 polymorphic microsatellite markers in the candidate regions. RESULTS: Evidence of linkage (p < 0,05) using non-parametric methods in chromosome 6p. Absence of linkage in 17q, 4q and 1cen-q21 regions. CONCLUSION: We present the evidence of a major gene in 6p21.3 involved in psoriasis in Spanish population.

KW - Candidate genes

KW - Genetic linkage

KW - Psoriasis

UR - http://www.scopus.com/inward/record.url?scp=0035898016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035898016&partnerID=8YFLogxK

M3 - Article

VL - 117

SP - 49

EP - 51

JO - Medicina Clinica

JF - Medicina Clinica

SN - 0025-7753

IS - 2

ER -