Analysis of pilocytic astrocytoma by comparative genomic hybridization

D. Sanoudou, O. Tingby, M. A. Ferguson-Smith, V. P. Collins, N. Coleman

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Abstract

Very little is known about genetic abnormalities involved in the development of pilocytic astrocytoma, the most frequently occurring brain tumour of childhood. We have analysed 48 pilocytic astrocytoma specimens using comparative genomic hybridization. Only five of 41 tumours from children showed abnormalities detectable by comparative genomic hybridization, and in each case this represented gain of a single chromosome. Interestingly, two of seven tumours from adults showed abnormalities, which were multiple and relatively complex. Six of the seven tumours showing abnormalities were from female patients (two adults and four children). The most frequently detectable abnormality was gain of 9q34.1-qter, which was present in three cases (two adult and one paediatric). (C) 2000 Cancer Research Campaign.

Original languageEnglish
Pages (from-to)1218-1222
Number of pages5
JournalBritish Journal of Cancer
Volume82
Issue number6
Publication statusPublished - 14 Mar 2000
Externally publishedYes

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Keywords

  • Comparative genomic hybridization
  • Glioma
  • Pilocytic astrocytoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sanoudou, D., Tingby, O., Ferguson-Smith, M. A., Collins, V. P., & Coleman, N. (2000). Analysis of pilocytic astrocytoma by comparative genomic hybridization. British Journal of Cancer, 82(6), 1218-1222.