An update on Vitamin D and B deficiency in the pathogenesis and treatment of diabetic neuropathy: A narrative review

Uazman Alam, Andrew J. Nelson, Daniel J. Cuthbertson, Rayaz Malik

Research output: Contribution to journalArticle

Abstract

Diabetic peripheral neuropathy (DPN) is highly prevalent and affects up to 50% of patients with diabetes. Painful neuropathic symptoms may occur in a third of patients with diabetes and is a major cause of sleep disturbance, morbidity and poor quality of life. Effective treatment of DPN remains a major challenge as current therapeutic options have a number of undesirable side effects and only provide a partial response to neuropathic pain. Furthermore, there are a lack of treatments that modulate the natural history of DPN. A growing body of evidence suggests that vitamin B and vitamin D may have analgesic effects and neuroprotective benefits in DPN. This narrative review explores the role of these vitamins in DPN. Given their limited side effects, further mechanistic studies and good quality randomized controlled trials of their putative analgesic ability are required to define the role of vitamin B and D in DPN.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalFuture Neurology
Volume13
Issue number3
DOIs
Publication statusPublished - 1 Aug 2018

Fingerprint

Vitamin B Deficiency
Vitamin D Deficiency
Diabetic Neuropathies
Peripheral Nervous System Diseases
Vitamin D
Vitamins
Analgesics
Therapeutics
Vitamin B Complex
Aptitude
Neuralgia
Sleep
Randomized Controlled Trials
Quality of Life
Morbidity

Keywords

  • deficiency
  • diabetic
  • neuropathy
  • peripheral
  • Vitamin B
  • Vitamin D

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

An update on Vitamin D and B deficiency in the pathogenesis and treatment of diabetic neuropathy : A narrative review. / Alam, Uazman; Nelson, Andrew J.; Cuthbertson, Daniel J.; Malik, Rayaz.

In: Future Neurology, Vol. 13, No. 3, 01.08.2018, p. 135-142.

Research output: Contribution to journalArticle

Alam, Uazman ; Nelson, Andrew J. ; Cuthbertson, Daniel J. ; Malik, Rayaz. / An update on Vitamin D and B deficiency in the pathogenesis and treatment of diabetic neuropathy : A narrative review. In: Future Neurology. 2018 ; Vol. 13, No. 3. pp. 135-142.
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