An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP)

C. Charles Gu, Steven Hunt, Sharon Kardia, Stephen T. Turner, Aravinda Chakravarti, Nicholas Schork, Richard Olshen, David Curb, Cashell Jaquish, Eric Boerwinkle, D. C. Rao

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The Family Blood Pressure Program (FBPP) has data on 387 microsatellite markers in 13,524 subjects from four major ethnic groups. We investigated genetic association with hypertension of the linkage markers. Family-based methods were used to test association of the 387 loci with resting blood pressures (BPs) [systolic blood pressure (SBP) and diastolic blood pressure (DBP)] and the hypertension status (HT). We applied a vote-counting approach to pool results across the three correlated traits, network samples, and ethnic groups to refine the selection of susceptibility loci. The association analyses captured signals missed by previous linkage scans. We found 71 loci associated with at least one of the three traits in at least one of the four ethnic groups at the significance level of 0.01. After validation across multiple samples and related traits, we identified by vote-counting 21 candidate loci for hypertension. Two loci, D3S2459 and D10S1412 confirmed findings in Network-specific linkage scans (GENOA and SAPPHIRe). Many of the candidate loci were reported by others in linkage to BPs, body weight, heart disease, and diabetes. We also observed frequent presence of quantitative trait loci (QTLs) involved in autoimmune and neurological disorders (e.g., NOD2). The vote-counting method of pooling results recognizes the potential that a gene may be involved in varying ways among different samples, which we believe is responsible for identifying genes in the less explored inflammatory pathways to hypertension.

Original languageEnglish
Pages (from-to)577-590
Number of pages14
JournalHuman Genetics
Volume121
Issue number5
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

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Microsatellite Repeats
Genome
Blood Pressure
Hypertension
Ethnic Groups
Quantitative Trait Loci
Nervous System Diseases
Genes
Heart Diseases
Body Weight

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP). / Gu, C. Charles; Hunt, Steven; Kardia, Sharon; Turner, Stephen T.; Chakravarti, Aravinda; Schork, Nicholas; Olshen, Richard; Curb, David; Jaquish, Cashell; Boerwinkle, Eric; Rao, D. C.

In: Human Genetics, Vol. 121, No. 5, 06.2007, p. 577-590.

Research output: Contribution to journalArticle

Gu, CC, Hunt, S, Kardia, S, Turner, ST, Chakravarti, A, Schork, N, Olshen, R, Curb, D, Jaquish, C, Boerwinkle, E & Rao, DC 2007, 'An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP)', Human Genetics, vol. 121, no. 5, pp. 577-590. https://doi.org/10.1007/s00439-007-0349-8
Gu, C. Charles ; Hunt, Steven ; Kardia, Sharon ; Turner, Stephen T. ; Chakravarti, Aravinda ; Schork, Nicholas ; Olshen, Richard ; Curb, David ; Jaquish, Cashell ; Boerwinkle, Eric ; Rao, D. C. / An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP). In: Human Genetics. 2007 ; Vol. 121, No. 5. pp. 577-590.
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