In this paper, we introduce a novel approach to interference cancellation for code division multiple access (CDMA) uplink transmission. Several models combining principles of serial (SIC) and parallel (PIC) interference cancellation are discussed. The proposed scheme is derived from the analysis of these hybrid models and applies a user configuration algorithm (termed "trickle") in order to provide improved bit-error-rate (BER) performance. The algorithm utilizes an adaptive matrix to compute the required configuration to be used for the subsequent interference cancellation stage. Bit-streaming, pipelined multiuser detection is employed and channel estimates are obtained using sample pilot data known at the receiver. We demonstrate that significant performance improvements can by achieved over various hybrid schemes. An improvement over the previous trickle model is also demonstrated where processing delay is greatly reduced while maintaining similar performance.