An evaluation of the metabolic syndrome in the HyperGEN study

Aldi T. Kraja, Steven Hunt, James S. Pankow, Richard H. Myers, Gerardo Heiss, Cora E. Lewis, D. C. Rao, Michael A. Province

Research output: Contribution to journalArticle

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Abstract

Background: In 2001 the National Cholesterol Education Program (NCEP) provided a categorical definition for metabolic syndrome (c-MetS). We studied the extent to which two ethnic groups, Blacks and Whites were affected by c-MetS. The groups were members of the Hypertension Genetic Epidemiology Network (HyperGEN), a part of the Family Blood Pressure Program, supported by the NHLBI. Although the c-MetS definition is of special interest in particular to the clinicians, the quantitative latent traits of the metabolic syndrome (MetS) are also important in order to gain further understanding of its etiology. In this study, quantitative evaluation of the MetS latent traits (q-MetS) was based on the statistical multivariate method factor analysis (FA). Results: The prevalence of the c-MetS was 34% in Blacks and 39% in Whites. c-MetS showed predominance of obesity, hypertension, and dyslipidemia. Three and four factor domains were identified through FA, classified as "Obesity," "Blood pressure," "Lipids," and "Central obesity." They explained approximately 60% of the variance in the 11 original variables. Two factors classified as "Obesity" and "Central Obesity" overlapped when FA was performed without rotation. All four factors in FA with Varimax rotation were consistent between Blacks and Whites, between genders and also after excluding type 2 diabetes (T2D) participants. Fasting insulin (INS) associated mainly with obesity and lipids factors. Conclusions: MetS in the HyperGEN study has a compound phenotype with separate domains for obesity, blood pressure, and lipids. Obesity and its relationship to lipids and insulin is clearly the dominant factor in MetS. Linkage analysis on factor scores for components of MetS, in familial studies such as HyperGEN, can assist in understanding the genetic pathways for MetS and their interactions with the environment, as a first step in identifying the underlying pathophysiological causes of this syndrome.

Original languageEnglish
JournalNutrition and Metabolism
Volume2
DOIs
Publication statusPublished - 18 Jan 2005
Externally publishedYes

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Molecular Epidemiology
Hypertension
Obesity
Statistical Factor Analysis
Lipids
Abdominal Obesity
Blood Pressure
Insulin
National Heart, Lung, and Blood Institute (U.S.)
Dyslipidemias
Metabolic Networks and Pathways
Ethnic Groups
Type 2 Diabetes Mellitus
Fasting

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Kraja, A. T., Hunt, S., Pankow, J. S., Myers, R. H., Heiss, G., Lewis, C. E., ... Province, M. A. (2005). An evaluation of the metabolic syndrome in the HyperGEN study. Nutrition and Metabolism, 2. https://doi.org/10.1186/1743-7075-2-2

An evaluation of the metabolic syndrome in the HyperGEN study. / Kraja, Aldi T.; Hunt, Steven; Pankow, James S.; Myers, Richard H.; Heiss, Gerardo; Lewis, Cora E.; Rao, D. C.; Province, Michael A.

In: Nutrition and Metabolism, Vol. 2, 18.01.2005.

Research output: Contribution to journalArticle

Kraja, AT, Hunt, S, Pankow, JS, Myers, RH, Heiss, G, Lewis, CE, Rao, DC & Province, MA 2005, 'An evaluation of the metabolic syndrome in the HyperGEN study', Nutrition and Metabolism, vol. 2. https://doi.org/10.1186/1743-7075-2-2
Kraja, Aldi T. ; Hunt, Steven ; Pankow, James S. ; Myers, Richard H. ; Heiss, Gerardo ; Lewis, Cora E. ; Rao, D. C. ; Province, Michael A. / An evaluation of the metabolic syndrome in the HyperGEN study. In: Nutrition and Metabolism. 2005 ; Vol. 2.
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AU - Rao, D. C.

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