An entropy-based approach to predict seizures in temporal lobe epilepsy using scalp EEG

Ali Shahidi Zandi, Guy A. Dumont, Manouchehr Javidan, Reza Tafreshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Citations (Scopus)

Abstract

We describe a novel algorithm for the prediction of epileptic seizures using scalp EEG. The method is based on the analysis of the positive zero-crossing interval series of the EEG signal and its first and second derivatives as a measure of brain dynamics. In a moving-window analysis, we estimated the probability density of these intervals and computed the differential entropy. The resultant entropy time series were then inspected using the cumulative sum (CUSUM) procedure to detect decreases as precursors of upcoming seizures. In the next step, the alarm sequences resulting from analysis of the EEG waveform and its derivatives were combined. Finally, a seizure prediction index was generated based on the spatio-temporal processing of the combined CUSUM alarms. We evaluated our algorithm using a dataset of ∼21.5 hours of multichannel scalp EEG recordings from four patients with temporal lobe epilepsy, resulting in 87.5% sensitivity, a false prediction rate of 0.28/hr, and an average prediction time of 25 min.

Original languageEnglish
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages228-231
Number of pages4
DOIs
Publication statusPublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: 2 Sep 20096 Sep 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period2/9/096/9/09

Fingerprint

Temporal Lobe Epilepsy
Entropy
Electroencephalography
Scalp
Seizures
Derivatives
Sequence Analysis
Time series
Epilepsy
Brain
Processing

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Zandi, A. S., Dumont, G. A., Javidan, M., & Tafreshi, R. (2009). An entropy-based approach to predict seizures in temporal lobe epilepsy using scalp EEG. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 228-231). [5333971] https://doi.org/10.1109/IEMBS.2009.5333971

An entropy-based approach to predict seizures in temporal lobe epilepsy using scalp EEG. / Zandi, Ali Shahidi; Dumont, Guy A.; Javidan, Manouchehr; Tafreshi, Reza.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 228-231 5333971.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zandi, AS, Dumont, GA, Javidan, M & Tafreshi, R 2009, An entropy-based approach to predict seizures in temporal lobe epilepsy using scalp EEG. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5333971, pp. 228-231, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 2/9/09. https://doi.org/10.1109/IEMBS.2009.5333971
Zandi AS, Dumont GA, Javidan M, Tafreshi R. An entropy-based approach to predict seizures in temporal lobe epilepsy using scalp EEG. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 228-231. 5333971 https://doi.org/10.1109/IEMBS.2009.5333971
Zandi, Ali Shahidi ; Dumont, Guy A. ; Javidan, Manouchehr ; Tafreshi, Reza. / An entropy-based approach to predict seizures in temporal lobe epilepsy using scalp EEG. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 228-231
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