An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

Abdelilah Arredouani, A. Mark Evans, Jianjie Ma, John Parrington, Michael X. Zhu, Antony Galione

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic β-cells.1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

Original languageEnglish
JournalIslets
Volume2
Issue number5
DOIs
Publication statusPublished - 1 Sep 2010
Externally publishedYes

Fingerprint

Insulin
Incretins
Glucagon-Like Peptide 1
Calcium Signaling
Adenine Nucleotides
Diphosphates
Calcium
Glucose
NAADP

Keywords

  • Calcium lysosome
  • NAADP
  • Pancreatic β-cell
  • Two-pore channel (TPC)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell. / Arredouani, Abdelilah; Evans, A. Mark; Ma, Jianjie; Parrington, John; Zhu, Michael X.; Galione, Antony.

In: Islets, Vol. 2, No. 5, 01.09.2010.

Research output: Contribution to journalArticle

Arredouani, Abdelilah ; Evans, A. Mark ; Ma, Jianjie ; Parrington, John ; Zhu, Michael X. ; Galione, Antony. / An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell. In: Islets. 2010 ; Vol. 2, No. 5.
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