An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

Abdelilah Arredouani, A. Mark Evans, Jianjie Ma, John Parrington, Michael X. Zhu, Antony Galione

Research output: Contribution to journalComment/debate

21 Citations (Scopus)


Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic β-cells.1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

Original languageEnglish
Issue number5
Publication statusPublished - 1 Sep 2010



  • Calcium lysosome
  • Pancreatic β-cell
  • Two-pore channel (TPC)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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