Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic β-cells.1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.
- Calcium lysosome
- Pancreatic β-cell
- Two-pore channel (TPC)
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism