A CMOS Digital Pixel Sensor (DPS) with reconfigurable coding (8/4-bit) and spatial (32 × 32/64 × 32) resolutions is proposed in this paper. The sensor is based on time domain coding which converts the photocurrent into an inversely proportional pulse width (PWM) signal. The 8-bit conversion mode is used for high quality imaging while the 4-bit conversion mode provides a shorter conversion time and a 2-fold increase in spatial resolution. In order to overcome the non-linearity introduced in the time domain PWM coding, a linearization procedure based on Non-Uniform Time domain quantizer is proposed. The reconfiguration features of the imager are demonstrated through experimental results obtained from a prototype designed using 1-poly, 5 metal CMOS 0.35μm n-well standard process.