AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation

Claudia Marinangeli, Sébastien Didier, Tariq Ahmed, Raphaelle Caillerez, Manon Domise, Charlotte Laloux, Séverine Bégard, Sébastien Carrier, Morvane Colin, Philippe Marchetti, Bart Ghesquière, Detlef Balschun, Luc Buée, Jérôme Kluza, Valérie Vingtdeux

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Although the brain accounts for only 2% of the total body mass, it consumes the most energy. Neuronal metabolism is tightly controlled, but it remains poorly understood how neurons meet their energy demands to sustain synaptic transmission. Here we provide evidence that AMP-activated protein kinase (AMPK)is pivotal to sustain neuronal energy levels upon synaptic activation by adapting the rate of glycolysis and mitochondrial respiration. Furthermore, this metabolic plasticity is required for the expression of immediate-early genes, synaptic plasticity, and memory formation. Important in this context, in neurodegenerative disorders such as Alzheimer disease, dysregulation of AMPK impairs the metabolic response to synaptic activation and processes that are central to neuronal plasticity. Altogether, our data provide proof of concept that AMPK is an essential player in the regulation of neuroenergetic metabolic plasticity induced in response to synaptic activation and that its deregulation might lead to cognitive impairments.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalFood Science and Human Wellness
Volume9
DOIs
Publication statusPublished - 30 Nov 2018

Fingerprint

AMP-activated protein kinase
AMP-Activated Protein Kinases
Neuronal Plasticity
Maintenance
energy
synaptic transmission
Immediate-Early Genes
neurodegenerative diseases
glycolysis
Glycolysis
Alzheimer disease
Synaptic Transmission
Neurodegenerative Diseases
breathing
Alzheimer Disease
Respiration
neurons
brain
Neurons
metabolism

Keywords

  • Cellular Neuroscience
  • Molecular Neuroscience
  • Neuroscience

ASJC Scopus subject areas

  • Food Science
  • General

Cite this

AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation. / Marinangeli, Claudia; Didier, Sébastien; Ahmed, Tariq; Caillerez, Raphaelle; Domise, Manon; Laloux, Charlotte; Bégard, Séverine; Carrier, Sébastien; Colin, Morvane; Marchetti, Philippe; Ghesquière, Bart; Balschun, Detlef; Buée, Luc; Kluza, Jérôme; Vingtdeux, Valérie.

In: Food Science and Human Wellness, Vol. 9, 30.11.2018, p. 1-13.

Research output: Contribution to journalArticle

Marinangeli, C, Didier, S, Ahmed, T, Caillerez, R, Domise, M, Laloux, C, Bégard, S, Carrier, S, Colin, M, Marchetti, P, Ghesquière, B, Balschun, D, Buée, L, Kluza, J & Vingtdeux, V 2018, 'AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation', Food Science and Human Wellness, vol. 9, pp. 1-13. https://doi.org/10.1016/j.isci.2018.10.006
Marinangeli, Claudia ; Didier, Sébastien ; Ahmed, Tariq ; Caillerez, Raphaelle ; Domise, Manon ; Laloux, Charlotte ; Bégard, Séverine ; Carrier, Sébastien ; Colin, Morvane ; Marchetti, Philippe ; Ghesquière, Bart ; Balschun, Detlef ; Buée, Luc ; Kluza, Jérôme ; Vingtdeux, Valérie. / AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation. In: Food Science and Human Wellness. 2018 ; Vol. 9. pp. 1-13.
@article{34073336d5024607baa8a784d52ee669,
title = "AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation",
abstract = "Although the brain accounts for only 2{\%} of the total body mass, it consumes the most energy. Neuronal metabolism is tightly controlled, but it remains poorly understood how neurons meet their energy demands to sustain synaptic transmission. Here we provide evidence that AMP-activated protein kinase (AMPK)is pivotal to sustain neuronal energy levels upon synaptic activation by adapting the rate of glycolysis and mitochondrial respiration. Furthermore, this metabolic plasticity is required for the expression of immediate-early genes, synaptic plasticity, and memory formation. Important in this context, in neurodegenerative disorders such as Alzheimer disease, dysregulation of AMPK impairs the metabolic response to synaptic activation and processes that are central to neuronal plasticity. Altogether, our data provide proof of concept that AMPK is an essential player in the regulation of neuroenergetic metabolic plasticity induced in response to synaptic activation and that its deregulation might lead to cognitive impairments.",
keywords = "Cellular Neuroscience, Molecular Neuroscience, Neuroscience",
author = "Claudia Marinangeli and S{\'e}bastien Didier and Tariq Ahmed and Raphaelle Caillerez and Manon Domise and Charlotte Laloux and S{\'e}verine B{\'e}gard and S{\'e}bastien Carrier and Morvane Colin and Philippe Marchetti and Bart Ghesqui{\`e}re and Detlef Balschun and Luc Bu{\'e}e and J{\'e}r{\^o}me Kluza and Val{\'e}rie Vingtdeux",
year = "2018",
month = "11",
day = "30",
doi = "10.1016/j.isci.2018.10.006",
language = "English",
volume = "9",
pages = "1--13",
journal = "Food Science and Human Wellness",
issn = "2213-4530",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation

AU - Marinangeli, Claudia

AU - Didier, Sébastien

AU - Ahmed, Tariq

AU - Caillerez, Raphaelle

AU - Domise, Manon

AU - Laloux, Charlotte

AU - Bégard, Séverine

AU - Carrier, Sébastien

AU - Colin, Morvane

AU - Marchetti, Philippe

AU - Ghesquière, Bart

AU - Balschun, Detlef

AU - Buée, Luc

AU - Kluza, Jérôme

AU - Vingtdeux, Valérie

PY - 2018/11/30

Y1 - 2018/11/30

N2 - Although the brain accounts for only 2% of the total body mass, it consumes the most energy. Neuronal metabolism is tightly controlled, but it remains poorly understood how neurons meet their energy demands to sustain synaptic transmission. Here we provide evidence that AMP-activated protein kinase (AMPK)is pivotal to sustain neuronal energy levels upon synaptic activation by adapting the rate of glycolysis and mitochondrial respiration. Furthermore, this metabolic plasticity is required for the expression of immediate-early genes, synaptic plasticity, and memory formation. Important in this context, in neurodegenerative disorders such as Alzheimer disease, dysregulation of AMPK impairs the metabolic response to synaptic activation and processes that are central to neuronal plasticity. Altogether, our data provide proof of concept that AMPK is an essential player in the regulation of neuroenergetic metabolic plasticity induced in response to synaptic activation and that its deregulation might lead to cognitive impairments.

AB - Although the brain accounts for only 2% of the total body mass, it consumes the most energy. Neuronal metabolism is tightly controlled, but it remains poorly understood how neurons meet their energy demands to sustain synaptic transmission. Here we provide evidence that AMP-activated protein kinase (AMPK)is pivotal to sustain neuronal energy levels upon synaptic activation by adapting the rate of glycolysis and mitochondrial respiration. Furthermore, this metabolic plasticity is required for the expression of immediate-early genes, synaptic plasticity, and memory formation. Important in this context, in neurodegenerative disorders such as Alzheimer disease, dysregulation of AMPK impairs the metabolic response to synaptic activation and processes that are central to neuronal plasticity. Altogether, our data provide proof of concept that AMPK is an essential player in the regulation of neuroenergetic metabolic plasticity induced in response to synaptic activation and that its deregulation might lead to cognitive impairments.

KW - Cellular Neuroscience

KW - Molecular Neuroscience

KW - Neuroscience

UR - http://www.scopus.com/inward/record.url?scp=85057161928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057161928&partnerID=8YFLogxK

U2 - 10.1016/j.isci.2018.10.006

DO - 10.1016/j.isci.2018.10.006

M3 - Article

AN - SCOPUS:85057161928

VL - 9

SP - 1

EP - 13

JO - Food Science and Human Wellness

JF - Food Science and Human Wellness

SN - 2213-4530

ER -