Ambient air pollution and adult asthma incidence in six european cohorts (Escape)

Bénédicte Jacquemin, Valérie Siroux, Margaux Sanchez, Anne Elie Carsin, Tamara Schikowski, Martin Adam, Valeria Bellisario, Anna Buschka, Roberto Bono, Bert Brunekreef, Yutong Cai, Marta Cirach, Françoise Clavel-Chapelon, Christophe Declercq, Roberto de Marco, Audrey De Nazelle, Regina E. Ducret-Stich, Virginia Valeria Ferretti, Margaret W. Gerbase, Rebecca Hardy & 26 others Joachim Heinrich, Christer Janson, Deborah Jarvis, Zeinab Al Kanaani, Dirk Keidel, Diana Kuh, Nicole Le Moual, Mark J. Nieuwenhuijsen, Alessandro Marcon, Lars Modig, Isabelle Pin, Thierry Rochat, Christian Schindler, Dorothea Sugiri, Morgane Stempfelet, Sofia Temam, Ming Yi Tsai, Raphaëlle Varraso, Danielle Vienneau, Andrea Vierkötter, Anna L. Hansell, Ursula Krämer, Nicole M. Probst-Hensch, Jordi Sunyer, Nino Künzli, Francine Kauffmann

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective: We aimed to investigate the association between air pollution and adult onset asthma. Methods: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. Results: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PM<inf>coarse</inf>. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m<sup>3</sup>; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m<sup>3</sup>; p = 0.08). Nonsignificant positive associations were estimated for PM<inf>10</inf> (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m<sup>3</sup>), PM<inf>2.5</inf> (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m<sup>3</sup>), PM<inf>2.5absorbance</inf> (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10<sup>−5</sup>/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative associa-tion was estimated for PM<inf>coarse</inf> (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m<sup>3</sup>). Conclusions: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.

Original languageEnglish
Pages (from-to)613-621
Number of pages9
JournalEnvironmental Health Perspectives
Volume123
Issue number6
DOIs
Publication statusPublished - 2015
Externally publishedYes

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Air Pollution
Asthma
Odds Ratio
Incidence
Nitrogen Oxides
Nitrogen Dioxide
Sex Education
Particulate Matter
Meta-Analysis
Buffers
Logistic Models
Smoking
Research

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Jacquemin, B., Siroux, V., Sanchez, M., Carsin, A. E., Schikowski, T., Adam, M., ... Kauffmann, F. (2015). Ambient air pollution and adult asthma incidence in six european cohorts (Escape). Environmental Health Perspectives, 123(6), 613-621. https://doi.org/10.1289/ehp.1408206

Ambient air pollution and adult asthma incidence in six european cohorts (Escape). / Jacquemin, Bénédicte; Siroux, Valérie; Sanchez, Margaux; Carsin, Anne Elie; Schikowski, Tamara; Adam, Martin; Bellisario, Valeria; Buschka, Anna; Bono, Roberto; Brunekreef, Bert; Cai, Yutong; Cirach, Marta; Clavel-Chapelon, Françoise; Declercq, Christophe; de Marco, Roberto; De Nazelle, Audrey; Ducret-Stich, Regina E.; Ferretti, Virginia Valeria; Gerbase, Margaret W.; Hardy, Rebecca; Heinrich, Joachim; Janson, Christer; Jarvis, Deborah; Al Kanaani, Zeinab; Keidel, Dirk; Kuh, Diana; Le Moual, Nicole; Nieuwenhuijsen, Mark J.; Marcon, Alessandro; Modig, Lars; Pin, Isabelle; Rochat, Thierry; Schindler, Christian; Sugiri, Dorothea; Stempfelet, Morgane; Temam, Sofia; Tsai, Ming Yi; Varraso, Raphaëlle; Vienneau, Danielle; Vierkötter, Andrea; Hansell, Anna L.; Krämer, Ursula; Probst-Hensch, Nicole M.; Sunyer, Jordi; Künzli, Nino; Kauffmann, Francine.

In: Environmental Health Perspectives, Vol. 123, No. 6, 2015, p. 613-621.

Research output: Contribution to journalArticle

Jacquemin, B, Siroux, V, Sanchez, M, Carsin, AE, Schikowski, T, Adam, M, Bellisario, V, Buschka, A, Bono, R, Brunekreef, B, Cai, Y, Cirach, M, Clavel-Chapelon, F, Declercq, C, de Marco, R, De Nazelle, A, Ducret-Stich, RE, Ferretti, VV, Gerbase, MW, Hardy, R, Heinrich, J, Janson, C, Jarvis, D, Al Kanaani, Z, Keidel, D, Kuh, D, Le Moual, N, Nieuwenhuijsen, MJ, Marcon, A, Modig, L, Pin, I, Rochat, T, Schindler, C, Sugiri, D, Stempfelet, M, Temam, S, Tsai, MY, Varraso, R, Vienneau, D, Vierkötter, A, Hansell, AL, Krämer, U, Probst-Hensch, NM, Sunyer, J, Künzli, N & Kauffmann, F 2015, 'Ambient air pollution and adult asthma incidence in six european cohorts (Escape)', Environmental Health Perspectives, vol. 123, no. 6, pp. 613-621. https://doi.org/10.1289/ehp.1408206
Jacquemin, Bénédicte ; Siroux, Valérie ; Sanchez, Margaux ; Carsin, Anne Elie ; Schikowski, Tamara ; Adam, Martin ; Bellisario, Valeria ; Buschka, Anna ; Bono, Roberto ; Brunekreef, Bert ; Cai, Yutong ; Cirach, Marta ; Clavel-Chapelon, Françoise ; Declercq, Christophe ; de Marco, Roberto ; De Nazelle, Audrey ; Ducret-Stich, Regina E. ; Ferretti, Virginia Valeria ; Gerbase, Margaret W. ; Hardy, Rebecca ; Heinrich, Joachim ; Janson, Christer ; Jarvis, Deborah ; Al Kanaani, Zeinab ; Keidel, Dirk ; Kuh, Diana ; Le Moual, Nicole ; Nieuwenhuijsen, Mark J. ; Marcon, Alessandro ; Modig, Lars ; Pin, Isabelle ; Rochat, Thierry ; Schindler, Christian ; Sugiri, Dorothea ; Stempfelet, Morgane ; Temam, Sofia ; Tsai, Ming Yi ; Varraso, Raphaëlle ; Vienneau, Danielle ; Vierkötter, Andrea ; Hansell, Anna L. ; Krämer, Ursula ; Probst-Hensch, Nicole M. ; Sunyer, Jordi ; Künzli, Nino ; Kauffmann, Francine. / Ambient air pollution and adult asthma incidence in six european cohorts (Escape). In: Environmental Health Perspectives. 2015 ; Vol. 123, No. 6. pp. 613-621.
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abstract = "Background: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective: We aimed to investigate the association between air pollution and adult onset asthma. Methods: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. Results: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95{\%} CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95{\%} CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95{\%} CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95{\%} CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95{\%} CI: 0.95, 1.19 per 10−5/m), traffic load (adjusted OR = 1.10; 95{\%} CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95{\%} CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative associa-tion was estimated for PMcoarse (adjusted OR = 0.98; 95{\%} CI: 0.87, 1.14 per 5 μg/m3). Conclusions: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.",
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TY - JOUR

T1 - Ambient air pollution and adult asthma incidence in six european cohorts (Escape)

AU - Jacquemin, Bénédicte

AU - Siroux, Valérie

AU - Sanchez, Margaux

AU - Carsin, Anne Elie

AU - Schikowski, Tamara

AU - Adam, Martin

AU - Bellisario, Valeria

AU - Buschka, Anna

AU - Bono, Roberto

AU - Brunekreef, Bert

AU - Cai, Yutong

AU - Cirach, Marta

AU - Clavel-Chapelon, Françoise

AU - Declercq, Christophe

AU - de Marco, Roberto

AU - De Nazelle, Audrey

AU - Ducret-Stich, Regina E.

AU - Ferretti, Virginia Valeria

AU - Gerbase, Margaret W.

AU - Hardy, Rebecca

AU - Heinrich, Joachim

AU - Janson, Christer

AU - Jarvis, Deborah

AU - Al Kanaani, Zeinab

AU - Keidel, Dirk

AU - Kuh, Diana

AU - Le Moual, Nicole

AU - Nieuwenhuijsen, Mark J.

AU - Marcon, Alessandro

AU - Modig, Lars

AU - Pin, Isabelle

AU - Rochat, Thierry

AU - Schindler, Christian

AU - Sugiri, Dorothea

AU - Stempfelet, Morgane

AU - Temam, Sofia

AU - Tsai, Ming Yi

AU - Varraso, Raphaëlle

AU - Vienneau, Danielle

AU - Vierkötter, Andrea

AU - Hansell, Anna L.

AU - Krämer, Ursula

AU - Probst-Hensch, Nicole M.

AU - Sunyer, Jordi

AU - Künzli, Nino

AU - Kauffmann, Francine

PY - 2015

Y1 - 2015

N2 - Background: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective: We aimed to investigate the association between air pollution and adult onset asthma. Methods: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. Results: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10−5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative associa-tion was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). Conclusions: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.

AB - Background: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective: We aimed to investigate the association between air pollution and adult onset asthma. Methods: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. Results: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10−5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative associa-tion was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). Conclusions: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.

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