Aluminium reduces glutamate-activated currents of rat hippocampal neurones

Bettina Platt, Helmut Haas, Dietrich Busselberg

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Abstract

Theactions of aluminium on glutamate-activated currents of acutely isolated hippocampal neurones were investigated. TV-methyl-D-aspartate (NMDA), a-amino- 3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and glutamate mediated currents were reduced by 50% in the presence of 1.4µg ml-1 aluminium. Higher concentrations (≥ 2.7 µg ml-1) inhibited all currents completely and irreversibly. Additionally, successive application of agonists in the presence of 2.7 µg ml'1 aluminium resulted in non-specific membrane currents followed by the loss of the seal resistance. Application of aluminium perse had no influence on resting membrane current or voltage-activated sodium currents. The estimation of the concen- tration-response relationship of the action of aluminium on NMDA-activated currents revealed a threshold concentration < 0.27 µg mb-1. Our data indicate that glutamate receptors are putative sites of action in aluminium neurotoxicity.

Original languageEnglish
Pages (from-to)2329-2332
Number of pages4
JournalNeuroReport
Volume5
Issue number17
Publication statusPublished - 1994
Externally publishedYes

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Keywords

  • Aluminium
  • Ampa
  • Glutamate-activated channels
  • Hippocampal neurons
  • Neurotoxicity
  • Nmda

ASJC Scopus subject areas

  • Neuroscience(all)

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