Altered lipid parameters in patients infected with Entamoeba histolytica, Entamoeba dispar and Giardia lamblia

Devendra Bansal, H. S. Bhatti, Rakesh Sehgal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Information on the effect of parasitic infections on lipid parameters is scarce. Certain parasites induce significant changes in lipid parameters, as demonstrated by the fact that substitution of lipid/cholesterol for serum in axenic culture medium (in vitro) and in experimental models (in vivo) supports vigorous growth of Entamoeba histolytica. Thus, significant changes in lipid parameters may be induced in an infected host. Blood samples are obtained from intestinal amoebiasis patients passing E. histolytica (n=8), E. dispar (n=15) or Giardia lamblia (n=9) cysts, or diagnosed with amoebic liver abscess (ALA; n=50) and from apparently normal healthy individuals (control group; n=30). Levels of total serum cholesterol, high-density lipoprotein and low-density lipoprotein are assessed using commercial kits. E. histolytica and E. dispar isolates are differentiated by hexokinase isoenzyme electrophoresis and by enzyme-linked immunosorbent assay (ELISA; Techlab) tests. Results show that E. histolytica, E. dispar and G. lamblia cyst passers had significantly lower levels of total serum cholesterol (73.42±2.24 mg/dL), compared to levels in ALA cases (101 ±2.85 mg/dL) and in controls (166.26±2.02 mg/dL). Further study of a greater number of cases is needed to explore the relevance of this finding.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalBritish Journal of Biomedical Science
Volume62
Issue number2
DOIs
Publication statusPublished - 1 Jan 2005
Externally publishedYes

Fingerprint

Entamoeba
Giardia lamblia
Entamoeba histolytica
Lipids
Cysts
Serum
Enzyme-Linked Immunosorbent Assay
Cholesterol
Axenic Culture
Amoebic Dysentery
Amoebic Liver Abscess
Immunosorbents
Parasitic Diseases
Hexokinase
Electrophoresis
LDL Lipoproteins
Liver
HDL Cholesterol
Isoenzymes
Culture Media

Keywords

  • Entamoeba dispar
  • Entamoeba histolytica
  • Giardia lamblia
  • Lipids

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)
  • Biochemistry, medical
  • Infectious Diseases

Cite this

Altered lipid parameters in patients infected with Entamoeba histolytica, Entamoeba dispar and Giardia lamblia. / Bansal, Devendra; Bhatti, H. S.; Sehgal, Rakesh.

In: British Journal of Biomedical Science, Vol. 62, No. 2, 01.01.2005, p. 63-65.

Research output: Contribution to journalArticle

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