Airway epithelial cells: Current concepts and challenges

Ronald Crystal, Scott H. Randell, John F. Engelhardt, Judith Voynow, Mary E. Sunday

Research output: Contribution to journalArticle

152 Citations (Scopus)


The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/ progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/ progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epitheliumin health and disease.

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalProceedings of the American Thoracic Society
Issue number7
Publication statusPublished - 1 Sep 2008
Externally publishedYes



  • Airway epithelium
  • Differentiation
  • Gene expression
  • Progenitor/stem cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology
  • Cell Biology

Cite this