Airway epithelial cells: Current concepts and challenges

Ronald Crystal, Scott H. Randell, John F. Engelhardt, Judith Voynow, Mary E. Sunday

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/ progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/ progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epitheliumin health and disease.

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalProceedings of the American Thoracic Society
Volume5
Issue number7
DOIs
Publication statusPublished - 1 Sep 2008
Externally publishedYes

Fingerprint

Stem Cells
Epithelial Cells
Epithelium
Lung
Bronchogenic Carcinoma
Cell Communication
Chronic Obstructive Pulmonary Disease
Cell Biology
Asthma
Air
Gene Expression
Health

Keywords

  • Airway epithelium
  • Differentiation
  • Gene expression
  • Progenitor/stem cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology
  • Cell Biology

Cite this

Airway epithelial cells : Current concepts and challenges. / Crystal, Ronald; Randell, Scott H.; Engelhardt, John F.; Voynow, Judith; Sunday, Mary E.

In: Proceedings of the American Thoracic Society, Vol. 5, No. 7, 01.09.2008, p. 772-777.

Research output: Contribution to journalArticle

Crystal, Ronald ; Randell, Scott H. ; Engelhardt, John F. ; Voynow, Judith ; Sunday, Mary E. / Airway epithelial cells : Current concepts and challenges. In: Proceedings of the American Thoracic Society. 2008 ; Vol. 5, No. 7. pp. 772-777.
@article{11c41a85398e4a649a45c40ea0ac1d58,
title = "Airway epithelial cells: Current concepts and challenges",
abstract = "The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/ progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/ progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epitheliumin health and disease.",
keywords = "Airway epithelium, Differentiation, Gene expression, Progenitor/stem cells",
author = "Ronald Crystal and Randell, {Scott H.} and Engelhardt, {John F.} and Judith Voynow and Sunday, {Mary E.}",
year = "2008",
month = "9",
day = "1",
doi = "10.1513/pats.200805-041HR",
language = "English",
volume = "5",
pages = "772--777",
journal = "Annals of the American Thoracic Society",
issn = "2325-6621",
publisher = "American Thoracic Society",
number = "7",

}

TY - JOUR

T1 - Airway epithelial cells

T2 - Current concepts and challenges

AU - Crystal, Ronald

AU - Randell, Scott H.

AU - Engelhardt, John F.

AU - Voynow, Judith

AU - Sunday, Mary E.

PY - 2008/9/1

Y1 - 2008/9/1

N2 - The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/ progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/ progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epitheliumin health and disease.

AB - The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/ progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/ progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epitheliumin health and disease.

KW - Airway epithelium

KW - Differentiation

KW - Gene expression

KW - Progenitor/stem cells

UR - http://www.scopus.com/inward/record.url?scp=50849093929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50849093929&partnerID=8YFLogxK

U2 - 10.1513/pats.200805-041HR

DO - 10.1513/pats.200805-041HR

M3 - Article

C2 - 18757316

AN - SCOPUS:50849093929

VL - 5

SP - 772

EP - 777

JO - Annals of the American Thoracic Society

JF - Annals of the American Thoracic Society

SN - 2325-6621

IS - 7

ER -